{"id":"W2031464903","doi":"10.1002/prot.22919","title":"Structures of parasitic CDPK domains point to a common mechanism of activation","year":2010,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Structural Genomics Consortium; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Ontario Innovation Trust; Wellcome Trust; Novartis Foundation; Ontario Genomics Institute; Merck; GlaxoSmithKline","keywords":"Mechanism (biology); Apicomplexa; Biology; Conformational change; Protein structure; Computational biology; Cell biology; Sequence (biology); Kinase; Biophysics; Plasmodium falciparum; Biochemistry; Physics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009299235,0.0001408638,0.0001581927,0.00007421193,0.00005735078,0.00001487574,0.0001033087,0.0001691983,0.00004673945],"category_scores_gemma":[0.0001290373,0.0001163769,0.00005056917,0.0001047124,0.00007198662,0.00001123643,0.00005347463,0.000119021,7.588723e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005104183,"about_ca_system_score_gemma":0.00004603627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007468331,"about_ca_topic_score_gemma":0.00001449815,"domain_scores_codex":[0.9992426,0.00001790376,0.000317672,0.0001242239,0.0001727063,0.000124871],"domain_scores_gemma":[0.999272,0.000009630335,0.0002135816,0.0002909235,0.000121166,0.00009272197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001608635,0.00001631865,0.0006432402,0.0001363703,0.00003354521,9.04901e-8,0.0001754684,0.00006184213,0.9902498,0.006656783,0.00006336095,0.001802289],"study_design_scores_gemma":[0.0004702734,0.0004861286,0.00593026,0.00002164955,0.00002708366,0.00000976174,0.0001800776,0.0002105424,0.9848857,0.007409469,0.000230904,0.0001381796],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9279678,0.000009133494,0.07106237,0.00004639471,0.0001636538,0.0004374015,0.0001085959,0.00001220078,0.0001924026],"genre_scores_gemma":[0.9782535,0.000001527989,0.02136056,0.0002016116,0.00005723571,0.00001090538,0.00009413099,0.0000107567,0.000009785708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05028564,"threshold_uncertainty_score":0.4745713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005729244152178639,"score_gpt":0.2268647110411472,"score_spread":0.2211354668889686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}