{"id":"W2031464903","doi":"10.1002/prot.22919","title":"Structures of parasitic CDPK domains point to a common mechanism of activation","year":2010,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Structural Genomics Consortium; Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Ontario Innovation Trust; Wellcome Trust; Novartis Foundation; Ontario Genomics Institute; Merck; GlaxoSmithKline","keywords":"Mechanism (biology); Apicomplexa; Biology; Conformational change; Protein structure; Computational biology; Cell biology; Sequence (biology); Kinase; Biophysics; Plasmodium falciparum; Biochemistry; Physics; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009941118,0.0002487205,0.0002012719,0.0002144107,0.0003442544,0.0004350473,0.0002216164,0.0003630726,0.001409818],"category_scores_gemma":[0.0002856595,0.0001374228,0.0002565339,0.0002093261,0.0004564275,0.0005181883,0.0002710652,0.0006674487,0.0003701695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004527862,"about_ca_system_score_gemma":0.0002794935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006230245,"about_ca_topic_score_gemma":0.0006504621,"domain_scores_codex":[0.9999483,0.000006762848,0.000004688305,0.00001528115,0.0000135466,0.00001143024],"domain_scores_gemma":[0.9998888,0.0000189594,0.00003417828,0.00001990982,0.00001773746,0.00002043027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004265128,0.00002962023,0.003995172,0.0003344824,0.00003871472,0.001284736,0.0004014726,0.002920422,0.9698302,0.009893025,0.0005575857,0.01028808],"study_design_scores_gemma":[0.0001463133,0.0004833262,0.06499128,0.00007065701,0.0001290035,0.01030501,0.0007579582,0.02683447,0.8300919,0.01563139,0.05044811,0.0001105573],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637963,0.002245149,0.02517764,0.000476883,0.00004094543,0.00005328184,0.0007560804,0.0002203264,0.007233471],"genre_scores_gemma":[0.9917556,0.0004415785,0.006366859,0.00003740795,0.000003449962,0.00001320677,0.0005309742,0.00001249189,0.0008385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409818,"threshold_uncertainty_score":0.004716337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005729244152178639,"score_gpt":0.2268647110411472,"score_spread":0.2211354668889686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}