{"id":"W2031481332","doi":"10.1073/pnas.0506176102","title":"Rtt106p is a histone chaperone involved in heterochromatin-mediated silencing","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; University of Toronto; National Institute of General Medical Sciences; Cancer Research UK","keywords":"Biology; Heterochromatin protein 1; Heterochromatin; Genetics; Gene silencing; Nucleosome; Chromatin; Histone; Histone methylation; Chaperone (clinical); Histone code; Cell biology; Molecular biology; Gene; DNA methylation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006207867,0.0003262445,0.0003104853,0.0002033265,0.0001638097,0.0002507874,0.0001858118,0.0003095575,0.0006924496],"category_scores_gemma":[0.000124341,0.00009247412,0.0002201353,0.0002436205,0.0001330469,0.0001553505,0.0001893451,0.0002786477,0.0005222642],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129933,"about_ca_system_score_gemma":0.0001082335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221665,"about_ca_topic_score_gemma":0.0002524403,"domain_scores_codex":[0.9999299,0.000007358657,0.000005833114,0.00002077768,0.00002549319,0.00001064728],"domain_scores_gemma":[0.999916,0.00001036397,0.00002410381,0.000008973155,0.00001019503,0.00003038589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000477839,0.00001402528,0.0006041912,0.00002619611,0.000005706218,0.0002091965,0.000006077453,0.00009383862,0.996116,0.00004786824,0.00007407857,0.002755008],"study_design_scores_gemma":[0.00002470302,0.0001633938,0.018192,0.000008945059,0.00002524544,0.003157917,0.00002400048,0.002668339,0.969708,0.0001417858,0.005877415,0.000008318442],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914553,0.001452162,0.005292109,0.0001594521,0.00002323671,0.0000188945,0.0005787315,0.0002416183,0.0007784258],"genre_scores_gemma":[0.9889033,0.0008981069,0.006070321,0.00004817392,0.00001605544,0.00001909049,0.002113541,0.00004240275,0.001888866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006924496,"threshold_uncertainty_score":0.002316475,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01929517301113198,"score_gpt":0.2772911664531033,"score_spread":0.2579959934419713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}