{"id":"W2031498189","doi":"10.1016/j.bmcl.2010.11.084","title":"Azaindoles as potent CRTH2 receptor antagonists","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Stereochemistry; Pharmacokinetics; Antagonist; Structural isomer; Chemical synthesis; Structure–activity relationship; Receptor; Combinatorial chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002961715,0.0003314132,0.0002445215,0.00002630157,0.0001644573,0.00004719932,0.0004556927,0.0003179505,0.002053113],"category_scores_gemma":[0.0001868482,0.0003043464,0.0001512814,0.0001097752,0.000198558,0.000005739953,0.0001213354,0.0004428161,0.0001153196],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002789045,"about_ca_system_score_gemma":0.0001375942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002915087,"about_ca_topic_score_gemma":0.000003714632,"domain_scores_codex":[0.998156,0.00002828406,0.0003287782,0.0006214141,0.0003776369,0.0004878906],"domain_scores_gemma":[0.9989113,0.00001424812,0.0001432607,0.0005449128,0.00007656259,0.0003097236],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006526172,0.00004526117,0.0002494186,0.00003783131,0.00005164905,0.00002278983,0.00004423225,8.479905e-7,0.9898168,0.00001781853,0.008309819,0.00133831],"study_design_scores_gemma":[0.0005885806,0.00006387242,0.0001151813,0.0000282215,0.00002748284,0.0001867964,0.0001482968,0.000004642593,0.9366311,0.00002018995,0.06184126,0.0003443744],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934148,0.0002758629,0.0006251774,0.003809026,0.000889971,0.0001386955,0.00001658367,0.00004937325,0.0007805327],"genre_scores_gemma":[0.9929585,0.00009013909,0.0009898635,0.002563863,0.002530035,0.0000146705,0.000235675,0.00005934303,0.0005578576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05353145,"threshold_uncertainty_score":0.9999409,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003594928298812503,"score_gpt":0.2135843670780354,"score_spread":0.2099894387792229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}