{"id":"W2031498189","doi":"10.1016/j.bmcl.2010.11.084","title":"Azaindoles as potent CRTH2 receptor antagonists","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry Letters","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Chemistry; Pharmacology; Stereochemistry; Pharmacokinetics; Antagonist; Structural isomer; Chemical synthesis; Structure–activity relationship; Receptor; Combinatorial chemistry; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454659,0.0003837182,0.000514566,0.0002635558,0.0001993853,0.0003635698,0.0003904706,0.000294719,0.003130492],"category_scores_gemma":[0.0001285313,0.0001816949,0.0001490859,0.0001823054,0.0002099932,0.0003045279,0.000286187,0.0008239587,0.0008064604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00034724,"about_ca_system_score_gemma":0.0001201656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004663024,"about_ca_topic_score_gemma":0.001708433,"domain_scores_codex":[0.9999014,0.00002482446,0.00000568722,0.00001431677,0.00001940966,0.00003425877],"domain_scores_gemma":[0.9999661,0.000008450688,0.000006137749,0.00000362766,0.000003800432,0.00001191031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001510778,0.0001449187,0.000294492,0.0003027838,0.00005963202,0.0003781114,0.0001073046,0.001345195,0.947116,0.00434441,0.003098706,0.04129766],"study_design_scores_gemma":[0.001728726,0.00849077,0.005855548,0.00005883914,0.0001970632,0.001929215,0.00009640011,0.004225252,0.8793318,0.001504613,0.09647124,0.0001104878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8994271,0.05503996,0.01081934,0.001458687,0.0007358028,0.0003057595,0.001591509,0.000747215,0.02987465],"genre_scores_gemma":[0.9642733,0.01973007,0.003003152,0.0006005222,0.0001716729,0.000106709,0.0008467226,0.00004069314,0.01122724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003130492,"threshold_uncertainty_score":0.01047254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003594928298812503,"score_gpt":0.2135843670780354,"score_spread":0.2099894387792229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}