{"id":"W2031530131","doi":"10.1182/blood-2013-01-478834","title":"The E3 ubiquitin ligase UBR5 is recurrently mutated in mantle cell lymphoma","year":2013,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":142,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Mantle cell lymphoma; Ubiquitin ligase; Biology; DNA ligase; Lymphoma; Genetics; Ubiquitin-Protein Ligases; Cancer research; Ubiquitin; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0000896057,0.0001588432,0.0002037967,0.00005448002,0.00008593484,0.00005228253,0.00009840934,0.00006819268,0.0002935787],"category_scores_gemma":[0.0000306712,0.00009871009,0.00008927412,0.0001696217,0.0000428582,0.00005201276,0.00004612664,0.00005235766,0.001213672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007405331,"about_ca_system_score_gemma":0.00008886657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006039728,"about_ca_topic_score_gemma":0.00004048854,"domain_scores_codex":[0.9989378,0.00003604858,0.0002546335,0.0002435092,0.0001931667,0.0003348729],"domain_scores_gemma":[0.9992768,0.0001110189,0.000064549,0.0003533552,0.00005763608,0.0001366888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002998032,0.04020257,0.4839807,0.0003279652,0.0007345916,0.002434673,0.004354241,0.000001327724,0.01096322,0.0006043041,0.1260863,0.3300103],"study_design_scores_gemma":[0.02831489,0.0006286805,0.4112143,0.0002281207,0.0003280921,0.0001529455,0.0004955807,0.0001036998,0.5335317,0.0003541425,0.02436899,0.0002788399],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835278,0.002328262,2.619679e-7,0.002320454,0.00009912895,0.0005732455,0.000011092,0.00004304984,0.01109664],"genre_scores_gemma":[0.9967362,0.0006029747,0.00008444554,0.0006916747,0.00007924162,0.0002347647,0.00002337432,0.00002048742,0.001526891],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5225685,"threshold_uncertainty_score":0.999564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008018948697593554,"score_gpt":0.2282139790099812,"score_spread":0.2201950303123876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}