{"id":"W2031544562","doi":"10.1007/s12013-011-9201-9","title":"Investigation of siRNA-Loaded Polyethylenimine-Coated Human Serum Albumin Nanoparticle Complexes for the Treatment of Breast Cancer","year":2011,"lang":"en","type":"article","venue":"Cell Biochemistry and Biophysics","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Polyethylenimine; Transfection; Cytotoxicity; Human serum albumin; Dispersity; Small interfering RNA; Chemistry; Nanoparticle; Gene delivery; Biophysics; Molecular biology; Materials science; Nanotechnology; Biochemistry; In vitro; Biology; Polymer chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002474015,0.0001896279,0.000234335,0.0001274454,0.000162697,0.0002217102,0.0001952933,0.0003155891,0.0006031411],"category_scores_gemma":[0.0001846961,0.0001569608,0.000191497,0.0001056377,0.0001447792,0.0001493178,0.00007952803,0.0001583343,0.0001521527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000320455,"about_ca_system_score_gemma":0.0002156307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083227,"about_ca_topic_score_gemma":0.001460315,"domain_scores_codex":[0.999885,0.00002584323,0.000008503324,0.00002097324,0.0000417895,0.00001786227],"domain_scores_gemma":[0.9999236,0.00002574639,0.00001375504,0.000004636125,0.00002271383,0.000009570748],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007854524,0.00001653414,0.00004217319,0.00004987985,0.000005091783,0.00002422313,0.00001805591,0.00008107602,0.9988181,0.00003954448,0.00002020276,0.0008063608],"study_design_scores_gemma":[0.000009199294,0.0001498485,0.0004254435,0.000001597839,0.00001303911,0.00005317164,0.000006537776,0.0009642659,0.9978665,0.000005976079,0.0005022017,0.000002298363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937716,0.00178113,0.003097053,0.00008081369,0.0000209015,0.00004880106,0.00005906775,0.00003702003,0.001103804],"genre_scores_gemma":[0.9952629,0.0005988737,0.002054155,0.00004566323,0.000005144949,0.00002851491,0.00007862806,0.00001679522,0.001909516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001083227,"threshold_uncertainty_score":0.002325058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03272860480804939,"score_gpt":0.2457316107325269,"score_spread":0.2130030059244775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}