{"id":"W2031549854","doi":"10.1016/j.parkreldis.2012.07.001","title":"RGFP109, a histone deacetylase inhibitor attenuates l-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: A proof-of-concept study","year":2012,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"Krembil Foundation; Edmond J. Safra Philanthropic Foundation; Parkinson Society Canada; Canadian Institutes of Health Research; Parkinson Canada; Cure Parkinson's Trust","keywords":"Dyskinesia; MPTP; Marmoset; Parkinson's disease; Histone deacetylase; Dopamine; Pharmacology; Levodopa; Acetylation; Medicine; Internal medicine; Histone; Chemistry; Biology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000418417,0.0007238466,0.001115633,0.0004094427,0.0004081629,0.000439109,0.000731311,0.00104353,0.002203574],"category_scores_gemma":[0.0001978898,0.0002426771,0.0006980714,0.0002438215,0.0005668368,0.0004968182,0.0001806095,0.001668187,0.0004993365],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004454366,"about_ca_system_score_gemma":0.0005044867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001657125,"about_ca_topic_score_gemma":0.003392219,"domain_scores_codex":[0.999765,0.00003366998,0.00002302981,0.00004366558,0.00005654508,0.00007818901],"domain_scores_gemma":[0.9998616,0.00001980939,0.00003678811,0.00001415497,0.00001352701,0.00005413734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001449565,0.0004957504,0.0001154833,0.0001021063,0.00003920697,0.0001220587,0.00002542272,0.00007169163,0.9954538,0.0001043005,0.0001709243,0.001849744],"study_design_scores_gemma":[0.0009411829,0.008121102,0.003835094,0.00001247026,0.0001874435,0.000404322,0.00007662807,0.001110799,0.9837046,0.00005812514,0.001530676,0.00001760858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945017,0.001292954,0.001317965,0.0003337381,0.0001055165,0.0001994166,0.0007424965,0.0002029038,0.001303244],"genre_scores_gemma":[0.9906688,0.001443075,0.003312262,0.0001396857,0.00005871908,0.000250798,0.001339603,0.00004897519,0.002738114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002203574,"threshold_uncertainty_score":0.007371724,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705890140232536,"score_gpt":0.2849306872290632,"score_spread":0.2678717858267379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}