{"id":"W2031549854","doi":"10.1016/j.parkreldis.2012.07.001","title":"RGFP109, a histone deacetylase inhibitor attenuates l-DOPA-induced dyskinesia in the MPTP-lesioned marmoset: A proof-of-concept study","year":2012,"lang":"en","type":"article","venue":"Parkinsonism & Related Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"Krembil Foundation; Edmond J. Safra Philanthropic Foundation; Parkinson Society Canada; Canadian Institutes of Health Research; Parkinson Canada; Cure Parkinson's Trust","keywords":"Dyskinesia; MPTP; Marmoset; Parkinson's disease; Histone deacetylase; Dopamine; Pharmacology; Levodopa; Acetylation; Medicine; Internal medicine; Histone; Chemistry; Biology; Disease; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007513401,0.0005616605,0.0007475442,0.0003495301,0.0002421528,0.00002838151,0.000301393,0.0002247395,0.0001751738],"category_scores_gemma":[0.0001663711,0.0004052029,0.000284895,0.0009312194,0.0001438731,0.0002462017,0.00008877333,0.0005226778,0.00007968106],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001807609,"about_ca_system_score_gemma":0.000172685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004708748,"about_ca_topic_score_gemma":0.0000957091,"domain_scores_codex":[0.9963958,0.0004716959,0.0008250006,0.000650608,0.0007861933,0.0008706669],"domain_scores_gemma":[0.9982454,0.0001818124,0.0003598397,0.0007856916,0.00008585142,0.000341369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.006433671,0.09391706,0.2459191,0.0005458118,0.00351975,0.001478091,0.09343768,0.0001494082,0.01269651,0.0008142691,0.003709226,0.5373794],"study_design_scores_gemma":[0.1160692,0.01471981,0.6155435,0.001564003,0.007222695,0.0006696786,0.06262746,0.002628192,0.05341835,0.002742998,0.1184182,0.004375886],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885236,0.005381726,0.00003596805,0.0009461463,0.0003904896,0.003151848,0.00002343203,0.0001069858,0.001439825],"genre_scores_gemma":[0.9984763,0.00009575451,0.0002136909,0.0002194607,0.00007850887,0.0005287192,0.0000846223,0.00009077381,0.0002122128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5330035,"threshold_uncertainty_score":0.99984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01705890140232536,"score_gpt":0.2849306872290632,"score_spread":0.2678717858267379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}