{"id":"W2031566197","doi":"10.1159/000244137","title":"Prospective, Randomized, Controlled Evaluation of a Gentamicin Loading Dose in Neonates","year":2009,"lang":"en","type":"article","venue":"Biology of the Neonate","topic":"Antibiotics Pharmacokinetics and Efficacy","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Royal University Hospital","funders":"","keywords":"Medicine; Gentamicin; Dosing; Therapeutic index; Toxicity; Gestational age; Loading dose; Therapeutic drug monitoring; Creatinine; Regimen; Aminoglycoside; Prospective cohort study; Anesthesia; Internal medicine; Antibiotics; Pregnancy; Pharmacokinetics; Pharmacology; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005960636,0.001640803,0.004269256,0.0006611109,0.0005824418,0.001316955,0.001537726,0.003350326,0.003112491],"category_scores_gemma":[0.01245186,0.0009027692,0.001754286,0.0007743735,0.002115539,0.001202597,0.0005448885,0.002775377,0.0004966474],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001030679,"about_ca_system_score_gemma":0.002189534,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006981109,"about_ca_topic_score_gemma":0.00118348,"domain_scores_codex":[0.9938186,0.004466691,0.00060705,0.0005023709,0.0003570391,0.0002482463],"domain_scores_gemma":[0.9913594,0.003958588,0.002727946,0.0004912714,0.0004494747,0.001013304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9831829,0.005235396,0.0006580842,0.0006529097,0.0005133466,0.0000302564,0.00002991086,0.00013964,0.001047427,0.00009409471,0.0001669072,0.008249086],"study_design_scores_gemma":[0.8317976,0.1655713,0.001019359,0.00006303082,0.0004448263,0.00002879584,0.00002288519,0.0002349799,0.0004561431,0.00007740852,0.000271382,0.00001229544],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.968161,0.01170492,0.002230874,0.0005772448,0.001146256,0.01424324,0.0005841324,0.0001651193,0.001187181],"genre_scores_gemma":[0.9682281,0.004979103,0.007377068,0.001195176,0.0007196525,0.01614501,0.0004208194,0.00002977809,0.0009052538],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005960636,"threshold_uncertainty_score":0.03152329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01995262742686086,"score_gpt":0.3291929968442893,"score_spread":0.3092403694174284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}