{"id":"W2031623179","doi":"10.1007/s00439-010-0924-2","title":"Investigation of 15 of the top candidate genes for late-onset Alzheimer’s disease","year":2010,"lang":"en","type":"review","venue":"Human Genetics","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Institute on Aging; National Institutes of Health; Alzheimer's Research Trust","keywords":"Candidate gene; Genome-wide association study; Biology; Apolipoprotein E; Gene; Genetics; Disease; Single-nucleotide polymorphism; Internal medicine; Genotype; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001232433,0.0002859733,0.0008677901,0.0001199573,0.0001020162,0.00001084982,0.0002561403,0.0001908612,0.00007005084],"category_scores_gemma":[0.0000447884,0.0001807936,0.0005458885,0.0001545295,0.0003331492,0.0000160918,0.0001051657,0.0002035726,0.000008286444],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002700123,"about_ca_system_score_gemma":0.001173979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001969627,"about_ca_topic_score_gemma":0.0000203265,"domain_scores_codex":[0.9984426,0.00009954458,0.0005323085,0.0002795098,0.0003908881,0.0002550709],"domain_scores_gemma":[0.9980587,0.0000829984,0.0004172247,0.0008536762,0.0002226768,0.0003646781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003102506,0.0007967812,0.09674152,0.0557723,0.03117847,0.00004466837,0.0002277676,0.000003603952,0.00005778681,0.0003043617,0.004099839,0.8104627],"study_design_scores_gemma":[0.004178261,0.0009493529,0.06102813,0.01764892,0.1004373,0.00001839799,0.00001706412,0.00004951582,0.002056233,0.002595042,0.8099844,0.001037289],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02073102,0.975407,0.000001547208,0.00002492339,0.00009822619,0.002379577,0.001309049,0.00001074431,0.00003793077],"genre_scores_gemma":[0.01048239,0.9872709,0.0002380139,0.00002381032,0.0001607356,0.0002104704,0.001450355,0.00006895213,0.00009435695],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8094254,"threshold_uncertainty_score":0.7372548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1275533868603957,"score_gpt":0.3910229520600143,"score_spread":0.2634695651996186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}