{"id":"W2031632957","doi":"10.1016/s0957-4166(99)00497-8","title":"Glycomethanethiosulfonates: powerful reagents for protein glycosylation","year":2000,"lang":"en","type":"article","venue":"Tetrahedron Asymmetry","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":97,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Engineering and Physical Sciences Research Council; Natural Sciences and Engineering Research Council of Canada; American Academy of Periodontology Foundation","keywords":"Glycosylation; Chemistry; Reagent; Glycan; Subtilisin; Serine protease; Active site; Biochemistry; Site-directed mutagenesis; Serine; Glycoprotein; Enzyme; Stereochemistry; Protease; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.000300069,0.0003438752,0.0003550024,0.00008420068,0.0001412188,0.00007269565,0.0003764977,0.0003854978,0.01872878],"category_scores_gemma":[0.0002827108,0.0003575457,0.0002684848,0.0003159217,0.00007826548,0.0001742591,0.00002786917,0.0002918369,0.0003972742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001529101,"about_ca_system_score_gemma":0.00005498992,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004364499,"about_ca_topic_score_gemma":0.000005334072,"domain_scores_codex":[0.9979771,0.00002479782,0.0004857912,0.0005952291,0.0003785345,0.0005385989],"domain_scores_gemma":[0.9987696,0.0002074605,0.000131882,0.0006311472,0.0000713755,0.0001885504],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004575326,0.0002502979,0.0003387968,0.0004067543,0.000104053,0.00001619893,0.0001091819,0.00002263552,0.8620873,0.0001996977,0.001227073,0.1347805],"study_design_scores_gemma":[0.001056626,0.00004066556,0.0001365741,0.000107992,0.00005025331,0.00001592185,0.00007438575,0.0005838181,0.9045233,0.0009486806,0.09199692,0.0004649189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7970198,0.0002189769,0.0001068321,0.0001652144,0.00007183517,0.0002280487,0.0001288064,0.000259153,0.2018013],"genre_scores_gemma":[0.9590382,0.00002754193,0.001287971,0.00009823138,0.0003319256,0.0001004121,0.0002136625,0.00007009053,0.03883195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1629693,"threshold_uncertainty_score":0.9998876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01357814565880091,"score_gpt":0.2449832687538845,"score_spread":0.2314051230950836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}