{"id":"W2031674672","doi":"10.1172/jci65833","title":"Prognostically relevant gene signatures of high-grade serous ovarian carcinoma","year":2012,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":591,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Calgary","funders":"National Human Genome Research Institute; National Institute of General Medical Sciences; Duke-NUS Medical School; Medical Research Council; National Health and Medical Research Council; National Cancer Institute; Foundation Medicine; National Institutes of Health","keywords":"Oncology; Ovarian cancer; Internal medicine; Medicine; Serous carcinoma; Serous fluid; Context (archaeology); Ovarian carcinoma; Disease; Prognostic variable; Cancer; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001392034,0.0001335818,0.0006703021,0.00009724341,0.00002947646,0.00001130411,0.00008517721,0.000210952,0.00005904299],"category_scores_gemma":[0.002036538,0.00009225575,0.0002737149,0.0001608882,0.0001750242,0.0001805913,0.00002171032,0.0004460083,0.000008636217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006341952,"about_ca_system_score_gemma":0.000401536,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003766349,"about_ca_topic_score_gemma":0.0000025125,"domain_scores_codex":[0.9974035,0.0001937342,0.001569121,0.000133123,0.0004938699,0.0002066234],"domain_scores_gemma":[0.9970459,0.0007383394,0.001057204,0.000203415,0.0004054565,0.0005497021],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004294275,0.001451835,0.9772685,0.00009481628,0.0003858607,0.00008738077,0.0001968131,0.00003054447,0.003483446,0.004176516,0.002621133,0.009773767],"study_design_scores_gemma":[0.003214845,0.001865759,0.9678418,0.0002628597,0.0007039351,0.0001317513,0.00001929626,0.00005725201,0.02262283,0.002336429,0.0008603479,0.00008287684],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885148,0.001292935,0.000268967,0.00862043,0.0009238082,0.0002442313,0.000006830652,0.000009091241,0.0001188488],"genre_scores_gemma":[0.9672782,0.0002121039,0.0296461,0.0009717908,0.001825244,0.000004865944,0.00001172558,0.00001792145,0.00003207094],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02937713,"threshold_uncertainty_score":0.376208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0778061322023824,"score_gpt":0.3629663190847204,"score_spread":0.285160186882338,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}