{"id":"W2031687582","doi":"10.4161/mabs.28786","title":"Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies","year":2014,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"","keywords":"Pertuzumab; Trastuzumab; Antibody; Monoclonal antibody; Epitope; Phage display; Signal transduction; Cetuximab; Blocking antibody; Cancer research; Receptor tyrosine kinase; Paratope; Computational biology; Chemistry; Cancer; Breast cancer; Biology; Biochemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003186894,0.0006386854,0.0003520133,0.0003138492,0.0001251788,0.0004881607,0.0004631783,0.0002276527,0.0007926396],"category_scores_gemma":[0.0002023738,0.0002073249,0.0003256944,0.0002919637,0.0001944211,0.0002265028,0.0002534266,0.0006379948,0.0003801575],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004685328,"about_ca_system_score_gemma":0.0003525493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006455225,"about_ca_topic_score_gemma":0.001377321,"domain_scores_codex":[0.9997484,0.00005222237,0.00001484837,0.00002540941,0.00009574718,0.0000633955],"domain_scores_gemma":[0.9999454,0.00001187695,0.0000144668,0.000005936217,0.00001285906,0.000009466817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001057879,0.0002177612,0.0004344002,0.000102315,0.00002057924,0.0001848919,0.00002760359,0.00440232,0.9777461,0.0008508908,0.000312785,0.01559446],"study_design_scores_gemma":[0.00004826117,0.000607121,0.001618447,0.00001241554,0.00003421744,0.0003352232,0.00002930084,0.007873399,0.9791039,0.000296133,0.01002445,0.00001724964],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9417543,0.006446754,0.04312705,0.0004429167,0.00005152617,0.0002554305,0.0005858254,0.0002580966,0.007078157],"genre_scores_gemma":[0.9458955,0.006662724,0.04210718,0.0002452058,0.00002525775,0.0001286698,0.0007620968,0.00006266001,0.004110808],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.0007926396,"threshold_uncertainty_score":0.003399491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01658047661319813,"score_gpt":0.2834084194072785,"score_spread":0.2668279427940803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}