{"id":"W2031696432","doi":"10.1021/jm900888c","title":"1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2<i>H</i>-benzimidazol-2-ones: Potent, Selective, and Orally Efficacious Norepinephrine Reuptake Inhibitors","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Norepinephrine transporter; Pharmacology; Reuptake inhibitor; Norepinephrine; Reuptake; Selectivity; Dopamine; Transporter; Serotonin; Stereochemistry; Biochemistry; Internal medicine; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004969849,0.0003667903,0.0005283222,0.00005705308,0.00011037,0.00003217706,0.0003481499,0.0003379213,0.00009552557],"category_scores_gemma":[0.0009149305,0.0002515626,0.0001839846,0.0001984735,0.000130377,0.00001603016,0.00008967344,0.0005800406,0.000002574386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005998461,"about_ca_system_score_gemma":0.0002421807,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003297307,"about_ca_topic_score_gemma":0.000001305194,"domain_scores_codex":[0.997878,0.00006744227,0.0006621272,0.0004155804,0.0005218625,0.0004550388],"domain_scores_gemma":[0.9981283,0.00005105279,0.0007997294,0.0002229413,0.0002896019,0.0005083592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001395845,0.0002511929,0.0001497167,0.0001065565,0.0001044632,0.000234721,0.00004256718,0.00004818066,0.9763581,0.000002021768,0.005356887,0.01594971],"study_design_scores_gemma":[0.003027588,0.003338577,0.001036233,0.0002351488,0.0001325595,0.00169562,0.00009356791,0.0001108998,0.9796414,0.000132655,0.01020439,0.0003513355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956726,0.00166111,0.0003384339,0.0009182545,0.0002140605,0.000200621,0.000005462059,0.00001909851,0.0009704037],"genre_scores_gemma":[0.9946778,0.001118651,0.0008315356,0.001116083,0.00181817,0.000005422161,0.00001506037,0.0000257798,0.0003914722],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01559838,"threshold_uncertainty_score":0.9999937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00860860486480869,"score_gpt":0.2625870162831774,"score_spread":0.2539784114183687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}