{"id":"W2031696432","doi":"10.1021/jm900888c","title":"1- or 3-(3-Amino-2-hydroxy-1-phenyl propyl)-1,3-dihydro-2<i>H</i>-benzimidazol-2-ones: Potent, Selective, and Orally Efficacious Norepinephrine Reuptake Inhibitors","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Pharmacological Receptor Mechanisms and Effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Norepinephrine transporter; Pharmacology; Reuptake inhibitor; Norepinephrine; Reuptake; Selectivity; Dopamine; Transporter; Serotonin; Stereochemistry; Biochemistry; Internal medicine; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006353715,0.0004017408,0.000303789,0.0001739804,0.0001028743,0.0001610569,0.0003501578,0.0002362513,0.001645549],"category_scores_gemma":[0.00006972792,0.0001202083,0.0001328903,0.0001501287,0.0001225364,0.0001776577,0.0001348063,0.000473005,0.0008062837],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002305489,"about_ca_system_score_gemma":0.0002089741,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006334194,"about_ca_topic_score_gemma":0.003086578,"domain_scores_codex":[0.9999509,0.000006329261,0.000004262432,0.000009082466,0.000009377855,0.00001999644],"domain_scores_gemma":[0.9999747,0.000002089354,0.00001024285,0.000002023337,0.000004005429,0.000006803679],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007093612,0.000267591,0.0002885435,0.0002693741,0.00002625469,0.0002843177,0.00003299042,0.0005615219,0.9718755,0.0006865417,0.0008831047,0.02411479],"study_design_scores_gemma":[0.001244091,0.007686876,0.01384183,0.00006020562,0.0001249666,0.002321579,0.00006686194,0.003150868,0.9345165,0.0003301634,0.03657893,0.00007717436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.955857,0.01975204,0.006787058,0.0004432619,0.000187047,0.00026429,0.001882674,0.0004205325,0.01440601],"genre_scores_gemma":[0.9752122,0.01126671,0.004438584,0.0002837546,0.00006591821,0.0001596686,0.001327227,0.0000247157,0.007221165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001645549,"threshold_uncertainty_score":0.005504847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00860860486480869,"score_gpt":0.2625870162831774,"score_spread":0.2539784114183687,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}