{"id":"W2031712266","doi":"10.1016/j.jmb.2005.09.004","title":"Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate-like Aza-peptide Epoxide","year":2005,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":181,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; Canadian Institutes of Health Research; University of Alberta","funders":"Canadian Institutes of Health Research; Faculty of Medicine and Dentistry, University of Alberta; Canada Research Chairs; Lawrence Berkeley National Laboratory; University of Alberta","keywords":"Stereochemistry; Peptide; Chemistry; Cysteine; Crystal structure; Substrate (aquarium); Enzyme; Crystallography; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003186545,0.0001884142,0.0004427413,0.00009167445,0.00007295638,0.00001493001,0.0002631056,0.0001623496,0.0002891482],"category_scores_gemma":[0.000182695,0.00009893806,0.0004956296,0.0002201342,0.0003227468,0.00004421293,0.00005841229,0.0004929579,0.000005815554],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000683423,"about_ca_system_score_gemma":0.000153701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001299697,"about_ca_topic_score_gemma":0.00009146969,"domain_scores_codex":[0.9982551,0.0003291001,0.0007141203,0.0001697602,0.0002975557,0.0002343345],"domain_scores_gemma":[0.9986153,0.0001113596,0.0006411119,0.0003275223,0.0001817254,0.0001230208],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002557907,0.00009728557,0.004768241,0.000005226945,0.0003007549,0.0001131599,0.0001029852,0.0000617429,0.9879144,0.0001480011,0.005423837,0.0008085734],"study_design_scores_gemma":[0.003677794,0.0004184814,0.04691616,0.000335986,0.0005180137,0.001175862,0.0005917082,0.00009287147,0.9355196,0.001477105,0.009045353,0.0002310271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926593,0.0009169453,0.0008337316,0.005121943,0.00005138578,0.0001187049,0.0001587875,0.000006959434,0.0001322797],"genre_scores_gemma":[0.993687,0.00004639292,0.001016062,0.00492096,0.0001759622,0.000001489849,0.00005024248,0.00001673014,0.0000851269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05239477,"threshold_uncertainty_score":0.4034577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01311228595915543,"score_gpt":0.2841481380403574,"score_spread":0.271035852081202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}