{"id":"W2031713647","doi":"10.1016/j.febslet.2008.08.032","title":"The role of a conserved histidine residue in a pyruvate‐specific Class II aldolase","year":2008,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Amino Acid Enzymes and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Histidine; Chemistry; Aldolase A; Stereochemistry; Cofactor; Alanine; Catalysis; Enzyme; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001382508,0.0001233536,0.000151259,0.00003451416,0.0001322374,0.000005699138,0.0002071958,0.000078742,0.000009625738],"category_scores_gemma":[0.00004315659,0.00009606182,0.00008150679,0.00009180208,0.0002122567,0.000002786831,0.0001010346,0.00009849291,0.000005120622],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001222628,"about_ca_system_score_gemma":0.00004061216,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000117391,"about_ca_topic_score_gemma":0.000106986,"domain_scores_codex":[0.9991302,0.00005932611,0.0002332569,0.0002206521,0.0001086605,0.0002478361],"domain_scores_gemma":[0.9994485,0.00001881479,0.00008429062,0.0003686592,0.00003186177,0.00004784343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001249491,0.00003317458,0.003888352,0.000003250764,0.00001673358,0.00001499313,0.0001164871,0.00002827416,0.9657568,0.0002510748,0.02922846,0.0005374004],"study_design_scores_gemma":[0.0005122325,0.00005202649,0.01163595,0.000006346576,0.000004209996,0.00001481238,0.00006263892,0.00001389654,0.4732276,0.00001925234,0.5143498,0.0001013033],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919899,0.00492965,0.00003946571,0.002096342,0.0001242359,0.000124085,0.00001238976,0.000007120088,0.000676854],"genre_scores_gemma":[0.9966782,0.001018576,0.0001995402,0.001210671,0.0001671835,0.00001963184,0.00003162027,0.00001704421,0.0006575784],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4925293,"threshold_uncertainty_score":0.3917287,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007837821076489802,"score_gpt":0.1947604753952404,"score_spread":0.1869226543187505,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}