{"id":"W2031715536","doi":"10.1073/pnas.0709691105","title":"Hydrogen peroxide scavenging rescues frataxin deficiency in a <i>Drosophila</i> model of Friedreich's ataxia","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":105,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; National Institutes of Health; Canadian Institutes of Health Research; Friedreich's Ataxia Research Alliance","keywords":"Frataxin; Ataxia; Reactive oxygen species; Aconitase; Biology; SOD2; Biochemistry; Superoxide; Mitochondrion; Phenotype; Ectopic expression; Enzyme; Superoxide dismutase; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048058,0.0003624289,0.0002666296,0.0002291831,0.0002091537,0.0002485569,0.0002733863,0.0003643021,0.0007904962],"category_scores_gemma":[0.00008674142,0.0001480063,0.000241894,0.00007956489,0.0002436002,0.0001479675,0.000174017,0.0006087007,0.0002713675],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003173729,"about_ca_system_score_gemma":0.0002262412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002118461,"about_ca_topic_score_gemma":0.003541694,"domain_scores_codex":[0.9999168,0.00001156789,0.00001097594,0.00001797045,0.00002230728,0.00002037152],"domain_scores_gemma":[0.9998702,0.00001294923,0.00004628865,0.00001051197,0.00001258303,0.00004741682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007329912,0.000041411,0.0001070741,0.00003709139,0.000006628212,0.00008340152,0.00001031724,0.00007863502,0.9980629,0.0001109509,0.0001289866,0.001259185],"study_design_scores_gemma":[0.00005365602,0.0007457194,0.006352449,0.00001791811,0.00003968814,0.0005403316,0.00005567915,0.001595202,0.9857886,0.0001052647,0.004693043,0.00001226173],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925465,0.001097859,0.002496055,0.0002801204,0.0000502624,0.00005553012,0.0005693806,0.0002903494,0.00261397],"genre_scores_gemma":[0.9906267,0.0008280582,0.002918291,0.0001186874,0.00001209597,0.00003786782,0.0005157572,0.0000677921,0.004874782],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002118461,"threshold_uncertainty_score":0.00421226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07763782584081237,"score_gpt":0.2931928405390546,"score_spread":0.2155550146982423,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}