{"id":"W2031728418","doi":"10.1074/jbc.m407477200","title":"Hyper-responsiveness to Stimulation of Human Immunodeficiency Virus-infected CD4+ T Cells Requires Nef and Tat Virus Gene Products and Results from Higher NFAT, NF-κB, and AP-1 Induction","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research","keywords":"NFAT; Priming (agriculture); Biology; T cell; Stimulation; Hyperactivation; Virus; HIV Long Terminal Repeat; Immune system; Transcription factor; Virology; Cell biology; Immunology; Gene expression; Gene; Long terminal repeat; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003055051,0.0001593358,0.0003320484,0.00005731,0.0001360777,0.00001895973,0.00009190317,0.0002599393,0.00005242503],"category_scores_gemma":[0.0003149,0.000108013,0.00003836807,0.0001112458,0.0003082041,0.00007866776,0.00009583243,0.0002608032,0.000005595172],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005522839,"about_ca_system_score_gemma":0.00005908606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001638287,"about_ca_topic_score_gemma":0.000002893941,"domain_scores_codex":[0.9988493,0.0001185987,0.000477873,0.0002840457,0.00006260069,0.0002076162],"domain_scores_gemma":[0.9991676,0.0001528672,0.0002837516,0.0001424295,0.0001870396,0.00006632532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001867052,0.000247579,0.001159167,0.00001619253,0.00008789115,0.00002138251,0.0001602883,0.00002136769,0.9945132,0.000003835455,0.00004602733,0.001856003],"study_design_scores_gemma":[0.002538292,0.0009329716,0.08606924,0.00005236845,0.00003187005,0.00009211342,0.00004866825,1.961889e-7,0.9093882,0.0001891844,0.0005520256,0.0001048592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946377,0.004602998,0.00001267061,0.0002879493,0.00008702539,0.0001370348,0.0001858112,0.00001005424,0.00003879788],"genre_scores_gemma":[0.9988725,0.0005944522,0.0002481528,0.0000189605,0.00006182034,0.000002998972,0.0001059348,0.000005900482,0.00008932497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08512501,"threshold_uncertainty_score":0.4404643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03384879162684916,"score_gpt":0.2813289509459392,"score_spread":0.2474801593190901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}