{"id":"W2031731997","doi":"10.1155/2012/123253","title":"NPM-ALK: The Prototypic Member of a Family of Oncogenic Fusion Tyrosine Kinases","year":2012,"lang":"en","type":"article","venue":"Journal of Signal Transduction","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Innovates; Alberta Innovates - Health Solutions; University of Alberta; Alberta Cancer Foundation","keywords":"Anaplastic lymphoma kinase; Cancer research; Chromosomal translocation; Fusion protein; Tyrosine kinase; Fusion gene; Kinase; Anaplastic large-cell lymphoma; Signal transduction; Receptor Protein-Tyrosine Kinases; Receptor tyrosine kinase; Lymphoma; Medicine; Biology; Gene; Lung cancer; Immunology; Cell biology; Genetics; Oncology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004159646,0.0001087771,0.000340618,0.0001090822,0.00003919194,0.00000378318,0.00005630556,0.00006007406,0.0002643796],"category_scores_gemma":[0.00001676551,0.00005944634,0.0002937834,0.0001819769,0.00007548683,0.0001682795,0.00000535286,0.0001104515,0.000003146531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008190411,"about_ca_system_score_gemma":0.0001056483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003647478,"about_ca_topic_score_gemma":0.000001274886,"domain_scores_codex":[0.9987573,0.00006044756,0.0005456752,0.00006532366,0.0004329995,0.0001382522],"domain_scores_gemma":[0.9990695,0.00005921012,0.000402334,0.0001142102,0.0002647563,0.00008999002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002491102,0.003408725,0.04291884,0.0002885105,0.0005462377,0.00001789918,0.001449898,0.00006578783,0.9061692,0.0001915386,0.0007301117,0.04172213],"study_design_scores_gemma":[0.003698577,0.002313398,0.2999984,0.0005286321,0.0010137,0.0006753242,0.0004707635,0.00001228382,0.6872715,0.00008362431,0.003860847,0.00007301023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939399,0.004048236,0.0001901496,0.0007851561,0.0002697912,0.0004319487,0.000004993246,0.00000408742,0.0003257019],"genre_scores_gemma":[0.9983633,0.0006248333,0.0004216907,0.00005713067,0.0004609678,0.00001247772,0.000002361046,0.00001083552,0.00004643402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2570795,"threshold_uncertainty_score":0.2894771,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0457370989671578,"score_gpt":0.3002504053257018,"score_spread":0.254513306358544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}