{"id":"W2031753048","doi":"10.1042/bj20041024","title":"Characterization of the survival motor neuron (SMN) promoter provides evidence for complex combinatorial regulation in undifferentiated and differentiated P19 cells","year":2005,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Medical Research Council; Natural Sciences and Engineering Research Council of Canada; Hospital for Sick Children; Muscular Dystrophy Canada; Canada Research Chairs; Canadian Institutes of Health Research; Sick Kids Foundation; ALS Society of Canada","keywords":"SMN1; Biology; Promoter; Transcription factor; Response element; Gene; Molecular biology; Transactivation; Cell biology; P19 cell; Genetics; Spinal muscular atrophy; Cellular differentiation; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001691144,0.0001014615,0.0001948869,0.00006965746,0.00005410262,0.00002958706,0.0000994876,0.00007866188,0.00003328153],"category_scores_gemma":[0.0001713455,0.0000691466,0.00008390319,0.0001205763,0.00008803988,0.00005832432,0.00005193105,0.0001841684,5.354128e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003809045,"about_ca_system_score_gemma":0.00006826433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000335203,"about_ca_topic_score_gemma":0.000001499075,"domain_scores_codex":[0.9989169,0.0001199562,0.0003131394,0.0001624942,0.0003097542,0.0001777259],"domain_scores_gemma":[0.9994527,0.0000614756,0.0001309483,0.0001249557,0.0001427416,0.00008724242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005652047,0.0002078017,0.008150981,0.000102108,0.00001846708,5.789481e-7,0.00004690553,3.432696e-7,0.9896017,0.00001542685,0.00004154125,0.00124895],"study_design_scores_gemma":[0.002032641,0.000171614,0.4969218,0.0001561933,0.00003722534,0.0000137059,0.000005106916,0.001941599,0.4985057,0.00006836039,0.00009361676,0.0000525068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974329,0.00007528946,0.0004286873,0.001052502,0.0001688868,0.0008240859,0.00000729961,0.000006646555,0.000003678641],"genre_scores_gemma":[0.9995062,0.00008553528,0.0001015576,0.0000403234,0.0001611761,0.00001066827,0.00002331105,0.00001434126,0.00005690481],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.491096,"threshold_uncertainty_score":0.2819717,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0550979917980851,"score_gpt":0.3125814844332936,"score_spread":0.2574834926352085,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}