{"id":"W2031758006","doi":"10.1074/jbc.m804813200","title":"Mutant Huntingtin N-terminal Fragments of Specific Size Mediate Aggregation and Toxicity in Neuronal Cells","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":143,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke","keywords":"Huntingtin; Huntingtin Protein; Cleavage (geology); Proteolysis; Mutant; Chemistry; Molecular biology; Epitope; Biochemistry; Biology; Cell biology; Antibody; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001654735,0.0001190761,0.0002256847,0.00002487577,0.00002643054,0.0000166339,0.0001864283,0.00006998787,0.0000920596],"category_scores_gemma":[0.0007946245,0.00008844895,0.00007077163,0.0001137595,0.0001363318,0.00004913187,0.00003874147,0.0002075122,9.296046e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001755565,"about_ca_system_score_gemma":0.0000264906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":1.969774e-7,"about_ca_topic_score_gemma":6.22638e-8,"domain_scores_codex":[0.9988242,0.00009954642,0.0004619704,0.0002138126,0.000239005,0.0001614157],"domain_scores_gemma":[0.9990982,0.0002743624,0.0004006757,0.00008109773,0.00003957908,0.0001060683],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001062659,0.0002139803,0.003520247,0.000009650745,8.582455e-7,0.00006712614,0.00001670267,0.0000313746,0.9938332,0.00000246166,0.00001256793,0.00218551],"study_design_scores_gemma":[0.0004133437,0.0002390011,0.07398094,0.00002950845,0.000003395732,0.00005869943,0.000009566195,0.00002488421,0.9247359,0.0004031829,0.00002848376,0.0000730832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994704,0.00006930609,0.00001079274,0.0001375464,0.00006534132,0.00005011141,0.00001216958,0.000003905252,0.0001804564],"genre_scores_gemma":[0.9991561,0.0003373029,0.0001923008,0.0001908994,0.0001085745,4.808301e-7,4.077961e-7,0.000003167749,0.00001082021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07046069,"threshold_uncertainty_score":0.3606844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02775810000504125,"score_gpt":0.2578927100345203,"score_spread":0.230134610029479,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}