{"id":"W2031770960","doi":"10.3390/molecules20034148","title":"Tethering in RNA: An RNA-Binding Fragment Discovery Tool","year":2015,"lang":"en","type":"article","venue":"Molecules","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"National Institute of General Medical Sciences; University of California, San Francisco; University of California, Davis; National Institutes of Health; Cancer Research Coordinating Committee","keywords":"Tethering; Small molecule; RNA; Chemistry; Cysteine; Thiol; Adduct; Nucleic acid; Biochemistry; Linker; Combinatorial chemistry; Stereochemistry; Biophysics; Cell biology; Biology; Enzyme; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003567412,0.0004502046,0.0004943685,0.0005137356,0.0002623611,0.0003877651,0.0006126416,0.0005701475,0.002263911],"category_scores_gemma":[0.0002872928,0.000257894,0.0003494098,0.0003216791,0.0002456218,0.0002514686,0.0003763544,0.0007337711,0.0008240819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002487388,"about_ca_system_score_gemma":0.0002357599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002653046,"about_ca_topic_score_gemma":0.0007730916,"domain_scores_codex":[0.999691,0.00004245664,0.00001265835,0.00006436282,0.0001598407,0.00002976877],"domain_scores_gemma":[0.9998698,0.00004718403,0.00002897624,0.00001846437,0.00001461339,0.00002087546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006118915,0.00003965574,0.0001011923,0.00006814928,0.00001377037,0.0001372004,0.00001657167,0.0002643433,0.9874737,0.0003900932,0.0001995672,0.01123445],"study_design_scores_gemma":[0.0000253722,0.0004006948,0.000496511,0.000004923615,0.00002884957,0.0004923951,0.000007804511,0.002072646,0.9889592,0.0001033762,0.007396768,0.00001151434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.6935043,0.007056789,0.2719929,0.001043148,0.0001847148,0.0007795057,0.002757285,0.008842823,0.01383865],"genre_scores_gemma":[0.7816094,0.00476699,0.1933342,0.0005047688,0.00006299098,0.0005364363,0.0025845,0.0002924885,0.01630834],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.002263911,"threshold_uncertainty_score":0.007573485,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02055042558475932,"score_gpt":0.2534929755408984,"score_spread":0.2329425499561391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}