{"id":"W2031775832","doi":"10.1007/s12035-015-9152-z","title":"Revisiting the Serotonin Hypothesis: Implications for Major Depressive Disorders","year":2015,"lang":"en","type":"review","venue":"Molecular Neurobiology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":245,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Serotonergic; Antidepressant; Major depressive disorder; Serotonin; Serotonin transporter; Animal models of depression; Psychology; Neuroscience; Neurotransmitter; Mood disorders; 5-HT receptor; Neurotransmission; Serotonin Plasma Membrane Transport Proteins; Medicine; Mood; Receptor; Psychiatry; Internal medicine; Central nervous system; Hippocampus; Anxiety","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003812481,0.0004886438,0.0008620198,0.00006800987,0.0002254445,0.0000475074,0.0007997787,0.0005372073,0.00001257813],"category_scores_gemma":[0.0003331579,0.0003430752,0.00072907,0.0001409462,0.0001062295,0.000002254201,0.0002716283,0.0002565173,0.00001648333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002264787,"about_ca_system_score_gemma":0.0002303453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003750769,"about_ca_topic_score_gemma":0.000002610846,"domain_scores_codex":[0.9975711,0.0005158341,0.0005184735,0.0008477024,0.00006389206,0.0004829872],"domain_scores_gemma":[0.9982918,0.0001424956,0.0004361848,0.000902959,0.0001274199,0.0000991789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001885612,0.0000235969,0.000003790444,0.001230817,0.0004065273,0.000002160653,0.000009317361,0.00003093741,0.028567,0.001101075,0.00190832,0.9666976],"study_design_scores_gemma":[0.0002271325,0.0001373542,0.000001626142,0.0002608013,0.0004757744,0.00005935436,0.000006064329,0.000002171253,0.001792215,0.0006913873,0.9959688,0.0003773331],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001039828,0.9868732,0.009740306,0.0003626674,0.0002669418,0.002159672,0.0002091291,0.00002694567,0.0002571726],"genre_scores_gemma":[0.000149566,0.994391,0.001186318,0.000466166,0.0005487512,0.001978511,0.0008752564,0.0001647322,0.0002396691],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9940605,"threshold_uncertainty_score":0.9999021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0394227741609685,"score_gpt":0.3131486623555879,"score_spread":0.2737258881946193,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}