{"id":"W2031822363","doi":"10.1038/npp.2014.3","title":"Long-Term Reduction of Cocaine Self-Administration in Rats Treated with Adenoviral Vector-Delivered Cocaine Hydrolase: Evidence for Enzymatic Activity","year":2014,"lang":"en","type":"article","venue":"Neuropsychopharmacology","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital","funders":"National Institute of General Medical Sciences; National Institute on Drug Abuse","keywords":"Self-administration; Butyrylcholinesterase; Pharmacology; Addiction; Cocaine dependence; Chemistry; Psychology; Anesthesia; Medicine; Neuroscience; Aché; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001385379,0.0005177546,0.0007284147,0.0003811316,0.0002245144,0.0003992202,0.0003586135,0.0005160421,0.002091233],"category_scores_gemma":[0.000212341,0.0002493457,0.0003952338,0.000189333,0.0005678337,0.0005092215,0.0002459473,0.00155965,0.0003750421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004293848,"about_ca_system_score_gemma":0.0005869223,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002014568,"about_ca_topic_score_gemma":0.004822915,"domain_scores_codex":[0.9998311,0.00001486545,0.000011764,0.00004736488,0.00003622128,0.0000586742],"domain_scores_gemma":[0.9995483,0.00002977997,0.00008344324,0.00006920136,0.00004624057,0.0002230688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002676417,0.0003573415,0.0007056239,0.00002351813,0.00002345563,0.00005147281,0.00003546413,0.00002698939,0.9935906,0.00006272899,0.00004828847,0.002398167],"study_design_scores_gemma":[0.00008125005,0.003525475,0.02328815,0.000008530754,0.00007646601,0.0001451064,0.000132005,0.001101876,0.9707172,0.0001157642,0.0007870022,0.00002117839],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976435,0.0004946652,0.0007234052,0.0001261635,0.00007482913,0.00002008689,0.0003519701,0.0000645965,0.0005008297],"genre_scores_gemma":[0.9916793,0.0005699795,0.001011429,0.00004980174,0.00001899759,0.00007102,0.0005987969,0.00003650647,0.005964141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002091233,"threshold_uncertainty_score":0.006995857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04685873513038678,"score_gpt":0.3512543838063906,"score_spread":0.3043956486760038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}