{"id":"W2031827468","doi":"10.1016/j.freeradbiomed.2007.01.018","title":"High levels of p66shc and intracellular ROS in permanently arrested early embryos","year":2007,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"Birth, Development, and Health","field":"Medicine","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Ontario Ministry of Food and Agriculture; University of Guelph","keywords":"Embryo; Oxidative stress; Intracellular; Biology; Reactive oxygen species; Cell biology; Senescence; Apoptosis; Embryogenesis; Andrology; Population; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001000987,0.0001557033,0.0005996974,0.0002170696,0.00005148328,0.000001246891,0.00007621467,0.0003319509,0.0001518902],"category_scores_gemma":[0.0003620721,0.0001088837,0.00001946375,0.0001713071,0.0009878875,0.00002492321,0.00004289296,0.0004153372,0.0000029457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002750647,"about_ca_system_score_gemma":0.00009637659,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004366734,"about_ca_topic_score_gemma":0.0001734263,"domain_scores_codex":[0.9986227,0.00006219069,0.0005269352,0.0002911512,0.0001278064,0.0003692842],"domain_scores_gemma":[0.9991066,0.0001987144,0.00009750832,0.0001966636,0.00004211283,0.0003583698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001198194,0.0002779826,0.6745006,0.0005967914,0.0001199812,0.0004295151,0.002525866,9.61181e-8,0.1272795,0.1561299,0.001451734,0.03548985],"study_design_scores_gemma":[0.00662032,0.001276975,0.97451,0.000300582,0.00005073249,0.0001573413,0.0001460562,0.0000185407,0.002947305,0.01234776,0.001510254,0.0001141358],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871035,0.004551397,0.0004880639,0.006604054,0.0002603087,0.0003115117,0.0000121469,0.00002286024,0.0006461202],"genre_scores_gemma":[0.98947,0.007737087,0.0008224093,0.001553267,0.0003061777,0.000003841827,0.00003418014,0.00001002066,0.00006301315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3000094,"threshold_uncertainty_score":0.4440149,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02360099514520055,"score_gpt":0.3047966391597722,"score_spread":0.2811956440145716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}