{"id":"W2031834135","doi":"10.1039/c2mt20033c","title":"Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium","year":2012,"lang":"en","type":"review","venue":"Metallomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; School of Medicine, New York University; York University; Barnard College; University of Miami","keywords":"Epigenome; Carcinogen; Histone; Demethylase; Carcinogenesis; Arsenic; Chemistry; Epigenetics; Enzyme; Methyltransferase; DNA methylation; Biology; Biochemistry; Methylation; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004209069,0.000934759,0.001207886,0.00172329,0.0002419316,0.0007707558,0.0007899736,0.001211721,0.00192409],"category_scores_gemma":[0.0004438867,0.0002355159,0.0003278855,0.002079136,0.000582562,0.001447584,0.0006917346,0.001276204,0.00118614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006771048,"about_ca_system_score_gemma":0.0009034597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001918633,"about_ca_topic_score_gemma":0.002239708,"domain_scores_codex":[0.9998772,0.00002496403,0.00001350945,0.00003220047,0.00004008774,0.00001214637],"domain_scores_gemma":[0.9998307,0.00006313747,0.00002195101,0.000007948627,0.00005508429,0.00002120568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008799318,0.00004824305,0.0004878132,0.01145842,0.0001410518,0.0003288777,0.0001085245,0.0005623758,0.005513299,0.00587277,0.02270703,0.9526836],"study_design_scores_gemma":[0.00001140156,0.0000759819,0.002512014,0.001551917,0.0001061195,0.001687657,0.0001159255,0.0001749519,0.00126665,0.004716722,0.9877538,0.00002673649],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001461768,0.9985656,0.0002047236,0.0003702864,0.0001195822,0.000001644456,0.00001152984,0.000005748896,0.0005746714],"genre_scores_gemma":[0.0009284763,0.9978917,0.0002177755,0.0001521744,0.0001972446,0.000003564679,0.00001983308,0.000001251305,0.0005879125],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00192409,"threshold_uncertainty_score":0.006436765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311160623074377,"score_gpt":0.2960692754255121,"score_spread":0.2529576691947683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}