{"id":"W2031834135","doi":"10.1039/c2mt20033c","title":"Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium","year":2012,"lang":"en","type":"review","venue":"Metallomics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":239,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Cancer Institute; National Institutes of Health; School of Medicine, New York University; York University; Barnard College; University of Miami","keywords":"Epigenome; Carcinogen; Histone; Demethylase; Carcinogenesis; Arsenic; Chemistry; Epigenetics; Enzyme; Methyltransferase; DNA methylation; Biology; Biochemistry; Methylation; DNA; Gene; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002027857,0.0003558088,0.001075476,0.00005289354,0.0001463506,0.00004269644,0.0002552798,0.0002948425,0.000004903375],"category_scores_gemma":[0.0001182457,0.000176473,0.0004273284,0.0001027255,0.0004636935,0.000003343435,0.0002899031,0.0002008091,0.000001835245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003041509,"about_ca_system_score_gemma":0.00005765518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001302396,"about_ca_topic_score_gemma":0.00001611768,"domain_scores_codex":[0.9980851,0.000738623,0.0004645556,0.0003277156,0.0001359393,0.000248091],"domain_scores_gemma":[0.998575,0.0003681862,0.0004130061,0.0005549945,0.00002280719,0.00006595399],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005761854,0.00008888546,0.0005328524,0.02792469,0.01241556,0.00000487161,0.0008944916,0.00004648097,0.02443316,0.009084105,0.00008733742,0.9239114],"study_design_scores_gemma":[0.001648458,0.0004426185,0.00003531884,0.0003508305,0.01044416,0.00004029331,0.00006596541,0.00003444112,0.006313066,0.0005206664,0.9794812,0.0006229781],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01245382,0.9856185,0.0005824247,0.00001919334,0.0001925796,0.0009014714,0.00003055747,0.000003254015,0.0001982522],"genre_scores_gemma":[0.06053992,0.9388916,0.00005365432,0.00001064828,0.0001789933,0.00004978438,0.00007627421,0.00004620641,0.0001528643],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9793939,"threshold_uncertainty_score":0.7196361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04311160623074377,"score_gpt":0.2960692754255121,"score_spread":0.2529576691947683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}