{"id":"W2031853664","doi":"10.1016/j.neuron.2007.01.024","title":"Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554","year":2007,"lang":"en","type":"letter","venue":"Neuron","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Centre National de la Recherche Scientifique; Association France Alzheimer","keywords":"Neprilysin; Presenilin; Downregulation and upregulation; Intracellular; Enzyme; Amyloid (mycology); Amyloid precursor protein; Chemistry; Nat; Biochemistry; Cell biology; Biology; Neuroscience; Alzheimer's disease; Internal medicine; Gene; Medicine; Disease; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001129092,0.0006074407,0.001014763,0.0004598881,0.0001409582,0.00005107365,0.0004624732,0.0004513357,0.0001520121],"category_scores_gemma":[0.0004745632,0.000461442,0.0004598427,0.0003877924,0.0004451077,0.0001154603,0.0001202613,0.001926366,0.00002476972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001415343,"about_ca_system_score_gemma":0.0005670491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001323173,"about_ca_topic_score_gemma":0.000007116857,"domain_scores_codex":[0.9934692,0.001619286,0.0008365547,0.0009483472,0.002309078,0.0008175126],"domain_scores_gemma":[0.9965616,0.001311654,0.0003663608,0.001050493,0.0002371256,0.0004727272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.03143838,0.0008838986,0.003684706,0.0003553557,0.002723988,0.003436368,0.0004044623,0.00004101889,0.3143381,0.00003482115,0.6419081,0.0007508334],"study_design_scores_gemma":[0.01776047,0.005396648,0.06360115,0.0009927837,0.003198778,0.0005420127,0.0001099974,0.0005235072,0.0463368,0.0001091158,0.8604177,0.001011061],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6003532,0.00834609,0.0005911173,0.3858662,0.0004747071,0.002812687,0.001362968,0.00005868168,0.0001343961],"genre_scores_gemma":[0.7886221,0.0003460362,0.00005820173,0.2092587,0.000252981,0.00008787859,0.0001888374,0.0001272926,0.001057954],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2680013,"threshold_uncertainty_score":0.9997838,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958646603650856,"score_gpt":0.2941760792462184,"score_spread":0.2745896132097099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}