{"id":"W2031853664","doi":"10.1016/j.neuron.2007.01.024","title":"Response to Correspondence: Pardossi-Piquard et al., “Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP.” Neuron 46, 541–554","year":2007,"lang":"en","type":"letter","venue":"Neuron","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Centre National de la Recherche Scientifique; Association France Alzheimer","keywords":"Neprilysin; Presenilin; Downregulation and upregulation; Intracellular; Enzyme; Amyloid (mycology); Amyloid precursor protein; Chemistry; Nat; Biochemistry; Cell biology; Biology; Neuroscience; Alzheimer's disease; Internal medicine; Gene; Medicine; Disease; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001588953,0.001391769,0.001738357,0.0008281525,0.002314001,0.002874792,0.00210201,0.02575561,0.01673307],"category_scores_gemma":[0.01081864,0.0006364917,0.001208923,0.0007133904,0.001583018,0.00206413,0.001058132,0.0288512,0.01523121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004574759,"about_ca_system_score_gemma":0.001594499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003408347,"about_ca_topic_score_gemma":0.005405362,"domain_scores_codex":[0.998519,0.000397015,0.0001670367,0.0002398955,0.0004212835,0.0002558327],"domain_scores_gemma":[0.9970545,0.001446594,0.0001334354,0.00008339874,0.0008709372,0.0004110883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002430107,0.00006229031,0.0002945414,0.00007892404,0.00002295176,0.002521738,0.00005525567,0.00007961484,0.0002149261,0.0005905731,0.9898548,0.005981389],"study_design_scores_gemma":[0.0005278754,0.0002421039,0.002714642,0.0002590225,0.00006877131,0.004466699,0.0004086984,0.0009029062,0.0008592476,0.0035921,0.9858631,0.00009471616],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007279245,0.002028646,0.0002044777,0.9346872,0.05696598,0.00008620387,0.0002521956,0.0001221911,0.004925156],"genre_scores_gemma":[0.007301771,0.00251418,0.0005119766,0.9038331,0.05129424,0.0001651276,0.000298341,0.00008055832,0.03400067],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.02575561,"threshold_uncertainty_score":0.0559777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01958646603650856,"score_gpt":0.2941760792462184,"score_spread":0.2745896132097099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}