{"id":"W2031857626","doi":"10.1161/circgenetics.111.960864","title":"Excess of Rare Variants in Non–Genome-Wide Association Study Candidate Genes in Patients With Hypertriglyceridemia","year":2011,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Lipid metabolism and disorders","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hamilton Health Sciences; McMaster University; Population Health Research Institute; Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Genome-wide association study; Candidate gene; Genetics; Biology; Genetic association; Gene; Single-nucleotide polymorphism; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001151249,0.0003822114,0.0004988831,0.001191947,0.0005452688,0.0004724219,0.0003936465,0.0007445311,0.003360385],"category_scores_gemma":[0.003169008,0.0001614676,0.0004733457,0.001043234,0.0004761615,0.0002257598,0.0003794569,0.0004890827,0.0002822724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001434043,"about_ca_system_score_gemma":0.0001698606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006414956,"about_ca_topic_score_gemma":0.001043385,"domain_scores_codex":[0.9988912,0.000346997,0.0001561096,0.000379963,0.0001559883,0.00006978079],"domain_scores_gemma":[0.9974313,0.001417335,0.0005934963,0.0002581218,0.0001217423,0.0001779866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001201611,0.0000704281,0.9674691,0.00006109996,0.0004696113,0.003732315,0.0002342594,0.0002049896,0.01919156,0.000199063,0.0003062162,0.006859888],"study_design_scores_gemma":[0.00005390434,0.0001507549,0.9888588,0.00001056916,0.0002721947,0.00735777,0.0001186117,0.0006719847,0.001804398,0.0002635591,0.0004268801,0.00001061776],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984824,0.0003761434,0.0006490503,0.00005168171,0.000007847269,0.000006610547,0.0001528754,0.00001646152,0.0002569265],"genre_scores_gemma":[0.9994054,0.00005550118,0.0002777818,0.00002693377,0.00001178461,0.000004538164,0.000142918,0.000004375554,0.00007079873],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003360385,"threshold_uncertainty_score":0.01124161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01291498170057683,"score_gpt":0.2106113373665964,"score_spread":0.1976963556660196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}