{"id":"W2031876838","doi":"10.1016/j.bbadis.2008.02.009","title":"Polymorphisms in the promoter regions for human MMP-1 and MMP-13 lead to differential responses to the alpha and beta isoforms of estrogen receptor and their ligand in vitro","year":2008,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Gene isoform; Estrogen receptor alpha; Estrogen receptor; Estrogen; Matrix metalloproteinase; Biology; Estrogen receptor beta; Promoter; Receptor; Alpha (finance); Endocrinology; Internal medicine; Gene expression; Genetics; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003581562,0.0003098938,0.0002924454,0.0004065527,0.0001133307,0.0002666957,0.0001923219,0.0002311165,0.002403409],"category_scores_gemma":[0.00070287,0.0003663744,0.0002426105,0.0002313736,0.0003411973,0.00009647953,0.0001754599,0.000514738,0.0003433108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001553186,"about_ca_system_score_gemma":0.0001048965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007522897,"about_ca_topic_score_gemma":0.0005320031,"domain_scores_codex":[0.9996824,0.0001106103,0.0000274105,0.00006343226,0.00005509146,0.00006106321],"domain_scores_gemma":[0.9992291,0.0004728327,0.0001199059,0.00006720672,0.00002980188,0.00008118623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003874222,0.0001959461,0.01027251,0.00002526412,0.00005549133,0.000475645,0.000137355,0.0001282084,0.9821457,0.0002754884,0.0001079414,0.002306127],"study_design_scores_gemma":[0.0005068819,0.00170691,0.2223302,0.00002649322,0.0002606225,0.006360944,0.0002762089,0.001995659,0.7633538,0.0008080692,0.002331752,0.00004258609],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998686,0.0002044981,0.0005959171,0.00003194199,0.00001377995,0.000006679722,0.0001906797,0.000009609192,0.0002607906],"genre_scores_gemma":[0.9984113,0.0001667498,0.000354601,0.00002708981,0.000006853362,0.000009426034,0.0003185101,0.00001666286,0.0006887565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002403409,"threshold_uncertainty_score":0.00804019,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01391358508802839,"score_gpt":0.2468760541879217,"score_spread":0.2329624690998933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}