{"id":"W2031880747","doi":"10.1016/j.chembiol.2012.12.008","title":"A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase","year":2013,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Polytechnique Montréal","funders":"National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Biology; Telomerase RNA component; RNA; Yeast; Reverse transcriptase; In vitro; Function (biology); Biochemistry; Molecular biology; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00006284467,0.0002107525,0.0004441644,0.00004970736,0.0000476645,0.0000107902,0.0001948657,0.0002687924,0.001525926],"category_scores_gemma":[0.000127913,0.0001839229,0.0001336362,0.0001646562,0.0005582454,0.00003697023,0.00009988512,0.0002203051,0.0001117567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003579048,"about_ca_system_score_gemma":0.00006788277,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002708927,"about_ca_topic_score_gemma":0.000002061903,"domain_scores_codex":[0.9986575,0.00001901494,0.0004512798,0.0003919156,0.0001279908,0.0003523317],"domain_scores_gemma":[0.999013,0.00003258791,0.0001380233,0.0004497491,0.0001550758,0.0002115336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002179542,0.0001166451,0.02599173,0.0001781846,0.00004424408,0.00001318824,0.00007795348,6.407191e-8,0.9681007,0.000007857341,0.002170454,0.003277245],"study_design_scores_gemma":[0.0006511154,0.00006478215,0.02311937,0.00007702727,0.0000437389,0.00008945275,0.0001508149,0.000008646155,0.9745936,0.0001541539,0.0008693425,0.0001779201],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968851,0.0005949636,0.000007778355,0.0002167856,0.00007480165,0.0001963946,0.0000221956,0.00006648189,0.001935538],"genre_scores_gemma":[0.9977749,0.00004239818,0.0003043603,0.0001294998,0.0004028132,0.00002978591,0.0001565086,0.00002223248,0.001137509],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006492997,"threshold_uncertainty_score":0.9993868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247130468579126,"score_gpt":0.2639533203118498,"score_spread":0.2514820156260585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}