{"id":"W2031880747","doi":"10.1016/j.chembiol.2012.12.008","title":"A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase","year":2013,"lang":"en","type":"article","venue":"Chemistry & Biology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer; Polytechnique Montréal","funders":"National Institute for Health and Care Research; Cancer Research UK; Wellcome Trust","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Biology; Telomerase RNA component; RNA; Yeast; Reverse transcriptase; In vitro; Function (biology); Biochemistry; Molecular biology; DNA; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001771023,0.0007239674,0.0005103734,0.0006810965,0.0001849534,0.0002967157,0.0003473512,0.0002822479,0.001565787],"category_scores_gemma":[0.0002065926,0.0002064975,0.0002875808,0.0005913625,0.000176253,0.0001266383,0.0002224792,0.0003580328,0.0004321043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002964146,"about_ca_system_score_gemma":0.0004346703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000976329,"about_ca_topic_score_gemma":0.003335014,"domain_scores_codex":[0.999828,0.00001955947,0.00001704602,0.00003540904,0.00007285176,0.00002720805],"domain_scores_gemma":[0.9998977,0.00002426856,0.00002359707,0.000009157509,0.00002521556,0.00001998232],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002442906,0.0001986745,0.0008864001,0.0001710618,0.00004327278,0.0003193345,0.00002130108,0.0007088165,0.981056,0.0002532169,0.000430019,0.01566755],"study_design_scores_gemma":[0.0001623493,0.002649034,0.004418096,0.00003186873,0.0001559385,0.001140867,0.00003704665,0.001493128,0.9783215,0.0001007588,0.01147093,0.00001852424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9590615,0.01224621,0.01268036,0.0003753608,0.0000788979,0.0006475454,0.005198376,0.0008026779,0.008908971],"genre_scores_gemma":[0.9581637,0.01092697,0.01562303,0.0002195684,0.00002471638,0.000249693,0.006872554,0.0000767762,0.007843109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001565787,"threshold_uncertainty_score":0.005238056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01247130468579126,"score_gpt":0.2639533203118498,"score_spread":0.2514820156260585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}