{"id":"W2031890346","doi":"10.1177/1947601910362446","title":"Wnt/ -catenin Pathway Modulates the Sensitivity of the Mutant FLT3 Receptor Kinase Inhibitors in a GSK-3  Dependent Manner","year":2010,"lang":"en","type":"article","venue":"Genes & Cancer","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; National Institutes of Health; University of Toronto; Johns Hopkins University; Leukemia and Lymphoma Society","keywords":"Wnt signaling pathway; Ectopic expression; Cell biology; Catenin; Tyrosine kinase; Signal transduction; Receptor tyrosine kinase; GSK-3; Cancer research; Biology; Haematopoiesis; Kinase; Gene knockdown; Chemistry; Stem cell; Cell culture; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005120365,0.0002001937,0.0001676316,0.00003091168,0.0001072661,0.00002013252,0.000279688,0.0001806889,0.00009478334],"category_scores_gemma":[0.00004397604,0.0001211967,0.0001175604,0.0001680846,0.0001770796,0.000005437836,0.0002144527,0.0002155865,0.000006469895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003183346,"about_ca_system_score_gemma":0.0002322727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006589434,"about_ca_topic_score_gemma":0.004541175,"domain_scores_codex":[0.9987143,0.0001226629,0.0002734234,0.0003580314,0.0002308578,0.0003006864],"domain_scores_gemma":[0.9993148,0.00002186357,0.0001438082,0.0003558992,0.0001162045,0.00004739519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005966805,0.00003312699,0.02564019,0.00001363932,0.00003959439,0.000002526111,0.0001965348,0.0005491229,0.9595416,0.00002160185,0.0006233945,0.01327897],"study_design_scores_gemma":[0.0003141745,0.00002009004,0.009909274,0.00003349584,0.00001454947,0.000006243507,0.00008744011,0.00008249425,0.9723049,0.00005123284,0.01698369,0.0001923604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953789,0.00207708,0.00002013845,0.0006711304,0.001426763,0.000275525,0.0000395187,0.000008814225,0.0001021156],"genre_scores_gemma":[0.9979419,0.0003537165,0.00008402064,0.0002130378,0.0004806656,0.0001171764,0.00001778693,0.0000278195,0.0007639118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01636029,"threshold_uncertainty_score":0.4942258,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006937748082740986,"score_gpt":0.2218185728985543,"score_spread":0.2148808248158133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}