{"id":"W203189154","doi":"10.2144/00293st04","title":"Yeast Recombinase FLP Functions Effectively in Human Cells for Construction of Adenovirus Vectors","year":2000,"lang":"en","type":"article","venue":"BioTechniques","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health","keywords":"FLP-FRT recombination; Recombinase; Recombinant DNA; Vector (molecular biology); Site-specific recombination; Plasmid; Cre recombinase; Biology; Cre-Lox recombination; Recombination; Transfection; Viral vector; Computational biology; Genetics; Genome; Virology; DNA; Genetic recombination; Gene; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001239592,0.0006205702,0.0006284536,0.000675452,0.0003575822,0.0008591523,0.0006430464,0.0005056901,0.00267292],"category_scores_gemma":[0.0004922025,0.0004200852,0.0004086297,0.000507797,0.0003436017,0.0004038941,0.0003536081,0.0014242,0.002940579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003949506,"about_ca_system_score_gemma":0.0006096811,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006486202,"about_ca_topic_score_gemma":0.0009160793,"domain_scores_codex":[0.999505,0.0001094885,0.00007095694,0.00008537648,0.0001701318,0.00005889767],"domain_scores_gemma":[0.9997848,0.00005851212,0.00002244765,0.00005503671,0.00003984757,0.00003947817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001477142,0.00004521487,0.0002031188,0.0002064265,0.00001540581,0.0001555358,0.00009216314,0.00020569,0.9834933,0.001951999,0.0009473982,0.0125361],"study_design_scores_gemma":[0.00005562876,0.0001267535,0.0004347991,0.00002380319,0.00002447785,0.0005548536,0.00002926954,0.001356516,0.9480585,0.0002905782,0.04903194,0.00001283086],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.2780653,0.009900614,0.6850321,0.0008946046,0.0009162324,0.002034123,0.008542541,0.003943679,0.01067083],"genre_scores_gemma":[0.5461092,0.01055036,0.4041744,0.0002516948,0.0001334765,0.001306738,0.01591046,0.0006701769,0.02089354],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.00267292,"threshold_uncertainty_score":0.00894177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465050089218646,"score_gpt":0.2979875883132509,"score_spread":0.2833370874210644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}