{"id":"W203189154","doi":"10.2144/00293st04","title":"Yeast Recombinase FLP Functions Effectively in Human Cells for Construction of Adenovirus Vectors","year":2000,"lang":"en","type":"article","venue":"BioTechniques","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Cancer Institute; Medical Research Council; National Institutes of Health","keywords":"FLP-FRT recombination; Recombinase; Recombinant DNA; Vector (molecular biology); Site-specific recombination; Plasmid; Cre recombinase; Biology; Cre-Lox recombination; Recombination; Transfection; Viral vector; Computational biology; Genetics; Genome; Virology; DNA; Genetic recombination; Gene; Transgene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002406944,0.0001120012,0.0001340617,0.000113003,0.00005831432,0.000008623232,0.0001195907,0.0002081027,0.000107187],"category_scores_gemma":[0.00001607003,0.0001168156,0.00007347633,0.0001346779,0.0001270275,0.000003876436,0.00002026852,0.00009284596,0.000005039764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003227715,"about_ca_system_score_gemma":0.0000484904,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008040911,"about_ca_topic_score_gemma":0.000111851,"domain_scores_codex":[0.9992156,0.00008965834,0.000183045,0.0002536262,0.00007846683,0.0001795944],"domain_scores_gemma":[0.9996033,0.00001117513,0.00004761216,0.0002413052,0.00005694962,0.00003964147],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008415288,0.00009656471,0.0001192231,0.00002532179,0.00001661651,5.056273e-7,0.00001279703,0.000005984352,0.9689631,0.00002518004,0.000629678,0.02926344],"study_design_scores_gemma":[0.0004516327,0.003442887,0.0003214839,0.0000223106,0.000005864845,0.000002672829,0.000012868,0.000005538102,0.9878367,0.0001775056,0.007601926,0.0001186037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975867,0.0001703177,0.0009429649,0.00002893322,0.000045419,0.000616234,0.00007836795,0.00003511948,0.0004959794],"genre_scores_gemma":[0.9975461,0.0001914258,0.001541035,0.00002529378,0.00006903001,0.0001367965,0.00006976882,0.00002377669,0.0003967687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02914483,"threshold_uncertainty_score":0.4763601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01465050089218646,"score_gpt":0.2979875883132509,"score_spread":0.2833370874210644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}