{"id":"W2031964028","doi":"10.1097/jto.0b013e3181ba2f1d","title":"Safety, Pharmacokinetics, and Pharmacodynamics of the Insulin-Like Growth Factor Type 1 Receptor Inhibitor Figitumumab (CP-751,871) in Combination with Paclitaxel and Carboplatin","year":2009,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Growth Hormone and Insulin-like Growth Factors","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Cancer Institute; Pfizer","keywords":"Medicine; Carboplatin; Pharmacodynamics; Pharmacokinetics; Paclitaxel; Internal medicine; Response Evaluation Criteria in Solid Tumors; Pharmacology; Lung cancer; Oncology; Adverse effect; Area under the curve; Dosing; Gastroenterology; Cancer; Chemotherapy; Progressive disease; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004974769,0.0002377205,0.0007140188,0.0002591054,0.00006225635,0.00001521749,0.0001475509,0.0002099498,0.00002657708],"category_scores_gemma":[0.0002581842,0.0001559291,0.00007953696,0.0004700148,0.0002065722,0.000223371,0.00005799893,0.0008498142,0.000001076901],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002453444,"about_ca_system_score_gemma":0.0003312268,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000202387,"about_ca_topic_score_gemma":0.00001250782,"domain_scores_codex":[0.9980218,0.0002388518,0.000888258,0.0002063593,0.0003845399,0.000260196],"domain_scores_gemma":[0.9981279,0.0002152451,0.0007870435,0.0001460035,0.0005214664,0.000202355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.03463383,0.003942919,0.2332698,0.0007203725,0.0006473299,0.0003589741,0.006992975,0.00004007502,0.3247617,0.000359015,0.003841232,0.3904318],"study_design_scores_gemma":[0.01789575,0.02000408,0.8970708,0.0008606021,0.0008605348,0.001308909,0.0009205583,0.001042445,0.04916009,0.0008602532,0.009458207,0.0005577523],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921616,0.001369288,0.00004282852,0.004955363,0.000652595,0.0003945984,0.0000210968,0.00001004239,0.000392636],"genre_scores_gemma":[0.9959427,0.001967203,0.001147097,0.0006790489,0.0001749768,0.000001389252,0.000007480156,0.00002175429,0.000058425],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.663801,"threshold_uncertainty_score":0.6358605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01482119092139858,"score_gpt":0.3341232052619967,"score_spread":0.3193020143405981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}