{"id":"W2031978749","doi":"10.1021/bi901605d","title":"Structural Control of Chemoselectivity, Stereoselectivity, and Substrate Specificity in Membrane-Bound Fatty Acid Acetylenases and Desaturases","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Plant Biotechnology Institute; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemoselectivity; Mutagenesis; Biochemistry; Enzyme; Amino acid; Substrate (aquarium); Fatty acid desaturase; Fatty acid; Stereoselectivity; Chemistry; Biology; Stereochemistry; Polyunsaturated fatty acid; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001660242,0.0002503252,0.0003286776,0.00003884828,0.00006436308,0.00004044033,0.0001343359,0.0002275528,0.000006544316],"category_scores_gemma":[0.00012343,0.0002267406,0.0000555781,0.0001102347,0.0001951832,0.00001262207,0.00005755644,0.0001193998,2.423292e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001203939,"about_ca_system_score_gemma":0.00007415371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002236403,"about_ca_topic_score_gemma":0.00004483236,"domain_scores_codex":[0.9988188,0.00004879272,0.0002479277,0.0004732308,0.0001287967,0.0002824603],"domain_scores_gemma":[0.9994363,0.00003144621,0.0001188565,0.0002535883,0.00005765389,0.0001021343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002191774,0.00007079065,0.03493926,0.00007211061,0.00002883928,0.000002208455,0.00002303195,6.64082e-7,0.9604243,0.000008203461,0.00001777049,0.004193659],"study_design_scores_gemma":[0.0008313882,0.00007819064,0.1596817,0.00002136595,0.0000217388,0.00003859118,0.0000314151,0.00001861842,0.8389883,0.00002869513,0.00004530509,0.000214673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968931,0.002619431,0.00003051692,0.00005988982,0.00003244899,0.0001450959,0.00005314342,0.00001214302,0.0001542025],"genre_scores_gemma":[0.9991857,0.0002204008,0.0002621066,0.00006894336,0.0001840505,0.0000041109,0.00003101843,0.00001171696,0.00003191467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1247424,"threshold_uncertainty_score":0.9246213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008467673239675108,"score_gpt":0.2238318488005172,"score_spread":0.2153641755608421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}