{"id":"W2031978749","doi":"10.1021/bi901605d","title":"Structural Control of Chemoselectivity, Stereoselectivity, and Substrate Specificity in Membrane-Bound Fatty Acid Acetylenases and Desaturases","year":2009,"lang":"en","type":"article","venue":"Biochemistry","topic":"Lipid metabolism and biosynthesis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"Plant Biotechnology Institute; University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemoselectivity; Mutagenesis; Biochemistry; Enzyme; Amino acid; Substrate (aquarium); Fatty acid desaturase; Fatty acid; Stereoselectivity; Chemistry; Biology; Stereochemistry; Polyunsaturated fatty acid; Mutant; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002085977,0.0002789659,0.0002589792,0.0001377455,0.0001184977,0.0003127497,0.0002642887,0.0002845782,0.0005177011],"category_scores_gemma":[0.0002420073,0.0001752168,0.0001959222,0.0001249647,0.0003211492,0.0002660953,0.0002273922,0.0003487691,0.0002774664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002573897,"about_ca_system_score_gemma":0.0001844742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003987715,"about_ca_topic_score_gemma":0.000597736,"domain_scores_codex":[0.9998705,0.00002739135,0.00001168295,0.00003171561,0.00003461617,0.00002405669],"domain_scores_gemma":[0.9997906,0.00004522933,0.00007675344,0.00002054876,0.00002557429,0.00004129823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004789243,0.000005961455,0.0002206509,0.0000108396,0.000002658468,0.00003531259,0.00001147911,0.0001016985,0.999008,0.00008027184,0.000003398303,0.000471947],"study_design_scores_gemma":[0.000009803671,0.00007427148,0.004318223,0.000003764572,0.0000101999,0.0002311257,0.00003764646,0.001238735,0.99331,0.00007372751,0.0006847004,0.000007866015],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971282,0.000490607,0.001987438,0.00002179061,0.000006548471,0.000006122151,0.00003568474,0.00002153551,0.0003021242],"genre_scores_gemma":[0.9983131,0.0001775735,0.001151382,0.00001492678,0.000002001072,0.000004272382,0.00005629623,0.00001047758,0.000270057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005177011,"threshold_uncertainty_score":0.001867473,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008467673239675108,"score_gpt":0.2238318488005172,"score_spread":0.2153641755608421,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}