{"id":"W2031984687","doi":"10.1016/j.tim.2014.01.007","title":"To acquire or resist: the complex biological effects of CRISPR–Cas systems","year":2014,"lang":"en","type":"review","venue":"Trends in Microbiology","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":125,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"CRISPR; Biology; Computational biology; DNA; Palindrome; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006322649,0.0008777856,0.001058106,0.001073019,0.000213285,0.001379676,0.001100256,0.001240173,0.001878449],"category_scores_gemma":[0.0007099038,0.0002433781,0.0003471773,0.001123561,0.0009112071,0.001432861,0.0006829454,0.002228752,0.00130091],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006707279,"about_ca_system_score_gemma":0.0008750616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000691621,"about_ca_topic_score_gemma":0.00144912,"domain_scores_codex":[0.9997182,0.00003280143,0.00002622501,0.00004847848,0.0001445228,0.00002967491],"domain_scores_gemma":[0.9996118,0.0002009654,0.00004939298,0.0000149845,0.00008480632,0.00003810186],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004369929,0.00003277573,0.0001425984,0.005888528,0.0000635659,0.0001241486,0.00005082843,0.0004840206,0.01016622,0.009743598,0.02490237,0.9483577],"study_design_scores_gemma":[0.00001014101,0.00004285112,0.0004314314,0.001014741,0.00005989366,0.0007159844,0.00005595335,0.0001663169,0.003374802,0.004776909,0.9893216,0.00002950565],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000355339,0.9943308,0.001496457,0.001083059,0.0004274489,0.000005557997,0.00002723445,0.00003738474,0.002236671],"genre_scores_gemma":[0.002165537,0.9945229,0.0009808718,0.0006841838,0.0002407855,0.00000813961,0.0000421498,0.000005497534,0.00134986],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001878449,"threshold_uncertainty_score":0.006283998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04346834040777872,"score_gpt":0.3920075890086491,"score_spread":0.3485392486008704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}