{"id":"W2032055079","doi":"10.1074/jbc.m106265200","title":"The N-terminal Globular Domain and the First Class A Amphipathic Helix of Apolipoprotein A-I Are Important for Lecithin:Cholesterol Acyltransferase Activation and the Maturation of High Density Lipoprotein in Vivo","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; University of Ottawa; Natural Sciences and Engineering Research Council of Canada; Heart and Stroke Foundation of Canada","keywords":"Chemistry; In vivo; Domain (mathematical analysis); Lecithin—cholesterol acyltransferase; Apolipoprotein B; Biochemistry; Cholesterol; Amphiphile; Acyltransferase; Cell biology; Biology; Genetics; Enzyme; Mathematics; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001031659,0.0001738011,0.0001266028,0.0000528411,0.00009108816,0.0001976002,0.0001356246,0.0002546939,0.0004226837],"category_scores_gemma":[0.0001156006,0.0001394269,0.0001329093,0.00004388854,0.0002193381,0.0001520884,0.000117369,0.0003492609,0.0002686613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002196126,"about_ca_system_score_gemma":0.000194366,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004879831,"about_ca_topic_score_gemma":0.0005268621,"domain_scores_codex":[0.9999141,0.00001405204,0.000007003124,0.00002186135,0.00002660182,0.00001637731],"domain_scores_gemma":[0.9998654,0.00001961888,0.00005630779,0.00001244675,0.00001301537,0.00003327106],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001018136,0.000008337027,0.0002529833,0.000008546324,0.00000120572,0.00002093837,0.000003889691,0.00002693377,0.9991053,0.00003212438,0.000004330707,0.000433647],"study_design_scores_gemma":[0.00002650554,0.0002121281,0.0152616,0.000004544286,0.00001163614,0.0003538257,0.00002651464,0.0008629163,0.9819475,0.00006628808,0.001220911,0.00000562019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981343,0.0004664366,0.001056851,0.00001817037,0.000005964802,0.000007286167,0.00004555145,0.00000837144,0.0002570864],"genre_scores_gemma":[0.9972156,0.0002374471,0.001656396,0.00002422499,0.000003718694,0.00001079049,0.0001748933,0.000004981528,0.0006719423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004879831,"threshold_uncertainty_score":0.001593411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01149830254105754,"score_gpt":0.2343842860136345,"score_spread":0.222885983472577,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}