{"id":"W2032112982","doi":"10.1016/j.cbpc.2009.01.001","title":"Effects of co-exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin and perfluorooctane sulfonate or perfluorooctanoic acid on expression of cytochrome P450 isoforms in chicken (Gallus gallus) embryo hepatocyte cultures","year":2009,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Per- and polyfluoroalkyl substances research","field":"Environmental Science","cited_by":29,"is_retracted":false,"has_abstract":false,"ca_institutions":"Environment and Climate Change Canada; Carleton University","funders":"","keywords":"Perfluorooctanoic acid; Perfluorooctane; Chemistry; Messenger RNA; Viability assay; Embryo; Hepatocyte; Internal medicine; Gene expression; Endocrinology; Andrology; Molecular biology; Cell; In vitro; Biology; Biochemistry; Sulfonate; Gene; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003253545,0.0004222585,0.0005166627,0.0002592324,0.0004133102,0.0004040882,0.0002641346,0.0004688422,0.001978672],"category_scores_gemma":[0.0002709621,0.0003071021,0.0005238908,0.0002786028,0.0004536168,0.0002777949,0.0003596629,0.000513956,0.0004787153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005914036,"about_ca_system_score_gemma":0.0005554638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005535792,"about_ca_topic_score_gemma":0.01475498,"domain_scores_codex":[0.9995115,0.0001325568,0.0000552032,0.0001085305,0.00006973728,0.0001226195],"domain_scores_gemma":[0.9995551,0.0001618852,0.00005288605,0.00005367833,0.00007376936,0.0001026564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002348284,0.0001164411,0.001253274,0.00005890716,0.00002781855,0.0002609796,0.0001352169,0.00008150341,0.9941842,0.00007227567,0.0001380868,0.001322933],"study_design_scores_gemma":[0.00005724001,0.001769658,0.02329268,0.00001204932,0.00007445519,0.0002951676,0.0003157477,0.000540629,0.9717607,0.00005197606,0.00181141,0.00001821842],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995541,0.001205355,0.000650923,0.0001351631,0.0001424581,0.00003415351,0.0004126465,0.00003069886,0.001847598],"genre_scores_gemma":[0.9883259,0.001155722,0.00117896,0.0001502645,0.00004465222,0.00007329331,0.001152925,0.00001958962,0.007898738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005535792,"threshold_uncertainty_score":0.01100713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01852513449395264,"score_gpt":0.3254241967658178,"score_spread":0.3068990622718651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}