{"id":"W2032124745","doi":"10.1074/jbc.275.12.8475","title":"The Lurcher Mutation of an α-Amino-3-hydroxy-5-methyl- 4-isoxazolepropionic Acid Receptor Subunit Enhances Potency of Glutamate and Converts an Antagonist to an Agonist","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Lunenfeld-Tanenbaum Research Institute; University of Toronto; SickKids Foundation; Mount Sinai Hospital","funders":"","keywords":"AMPA receptor; Kainate receptor; Glutamate receptor; Gamma-aminobutyric acid receptor subunit alpha-1; CNQX; Protein subunit; Kainic acid; Transmembrane domain; Biology; NMDA receptor; Alanine; Agonist; Biochemistry; Chemistry; Molecular biology; Receptor; Amino acid; G alpha subunit","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001599934,0.0005548174,0.0002864993,0.0001814549,0.0001182321,0.0002183642,0.0002888244,0.0003861024,0.002089003],"category_scores_gemma":[0.0001840448,0.0001586055,0.0003517621,0.00009453416,0.0003432457,0.0002287135,0.0001922633,0.0006109084,0.001339299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966554,"about_ca_system_score_gemma":0.0001480934,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002837169,"about_ca_topic_score_gemma":0.000440876,"domain_scores_codex":[0.99984,0.0000295229,0.00002594776,0.00003786281,0.00003271267,0.00003389911],"domain_scores_gemma":[0.9997831,0.00002896428,0.00009959306,0.00003358416,0.00001242753,0.00004233048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003896262,0.00001178045,0.00004497611,0.000007736205,0.000002768385,0.00006286655,0.000004104155,0.00001992709,0.9994018,0.00003922374,0.00001321589,0.0003525916],"study_design_scores_gemma":[0.00003841552,0.0004452726,0.002407141,0.000007154308,0.00001944131,0.001000335,0.00001232352,0.0004070922,0.9939944,0.00002768173,0.00163473,0.000005975465],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936944,0.0005229381,0.003515932,0.0001246324,0.0000386466,0.00004575906,0.0002804609,0.0001991974,0.001577942],"genre_scores_gemma":[0.9916686,0.0004737229,0.004184585,0.00009998856,0.00002303086,0.00004528772,0.0005489754,0.00006767779,0.002888022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002089003,"threshold_uncertainty_score":0.006988406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04134064067601165,"score_gpt":0.3345137381600844,"score_spread":0.2931730974840727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}