{"id":"W2032147202","doi":"10.1126/scitranslmed.3001571","title":"5-Lipoxygenase Metabolite 4-HDHA Is a Mediator of the Antiangiogenic Effect of ω-3 Polyunsaturated Fatty Acids","year":2011,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Eicosanoids and Hypertension Pharmacology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":255,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital Maisonneuve-Rosemont","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Eye Institute; Canadian Institutes of Health Research","keywords":"Polyunsaturated fatty acid; Docosahexaenoic acid; Lipoxygenase; Cyclooxygenase; Eicosapentaenoic acid; Angiogenesis; Lipid signaling; Pharmacology; Biochemistry; Biology; Chemistry; Cancer research; Fatty acid; Receptor; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000586041,0.000109855,0.0002107824,0.00008789314,0.0000759174,0.000001318544,0.0003491176,0.00005625643,0.0002061565],"category_scores_gemma":[0.0001021031,0.00006052455,0.0001013305,0.0004988315,0.001347383,0.000007557173,0.00003342862,0.00006300944,0.000001508282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002377587,"about_ca_system_score_gemma":0.0001788029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003636233,"about_ca_topic_score_gemma":0.000004416667,"domain_scores_codex":[0.9988781,0.00007498122,0.0002628164,0.000236002,0.0003743331,0.0001737251],"domain_scores_gemma":[0.9993219,0.00002856628,0.0001178294,0.0002400572,0.0002069846,0.00008470459],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001385231,0.00002477848,0.0168198,0.00001461905,0.00003468095,5.793976e-7,0.0002693649,0.000001620035,0.9818432,0.0001971545,0.0001366177,0.0005190152],"study_design_scores_gemma":[0.0008752478,0.0002884581,0.1092801,0.00001426428,0.00008644222,0.000009774202,0.00001735997,0.0000671639,0.8887074,0.00007849541,0.0005176588,0.00005769069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963775,0.001740874,0.0001574561,0.000767843,0.000353482,0.0001794815,0.00004064634,0.000003564865,0.0003791345],"genre_scores_gemma":[0.9990968,0.00007609089,0.0002674148,0.0004189359,0.00009027871,0.000004621586,0.00001483911,0.000006097587,0.00002488708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09313585,"threshold_uncertainty_score":0.4964488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723689842301181,"score_gpt":0.2781669634739546,"score_spread":0.2609300650509428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}