{"id":"W2032172756","doi":"10.1016/j.ygyno.2007.07.064","title":"p16 and MIB1 improve the sensitivity and specificity of the diagnosis of high grade squamous intraepithelial lesions: Methodological issues in a report of 447 biopsies with consensus diagnosis and HPV HCII testing","year":2007,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Reliability and Agreement in Measurement","field":"Decision Sciences","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Vancouver General Hospital; BC Cancer Agency","funders":"National Cancer Institute","keywords":"Medicine; Grading (engineering); Biopsy; Pathology; Atypia; Intraepithelial neoplasia; Internal medicine; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1147482,0.0007640204,0.001611986,0.002508039,0.001536225,0.00235192,0.002685444,0.00169107,0.0005686578],"category_scores_gemma":[0.2097994,0.001490895,0.002211538,0.002153551,0.002374012,0.001015224,0.001841607,0.001371613,0.0003188076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001333192,"about_ca_system_score_gemma":0.001277533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008168779,"about_ca_topic_score_gemma":0.01544589,"domain_scores_codex":[0.8524094,0.1043845,0.01428346,0.007075812,0.01958154,0.002265289],"domain_scores_gemma":[0.7031024,0.222427,0.01506753,0.02606831,0.03219316,0.001141611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002200455,0.0002275796,0.9535148,0.0005337234,0.003916752,0.0002681425,0.005004616,0.000939479,0.003374142,0.0003713113,0.0005302792,0.02911879],"study_design_scores_gemma":[0.0001987247,0.001435478,0.9690447,0.0001990236,0.003655117,0.001600374,0.002248404,0.004480556,0.01329239,0.0006609037,0.003101352,0.00008303408],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845361,0.003855555,0.008326978,0.000290491,0.0001220281,0.0002898681,0.0002480284,0.00002649132,0.002304482],"genre_scores_gemma":[0.9948856,0.0002193379,0.004223004,0.0001140741,0.00003725942,0.00009906608,0.0001883537,0.0000214234,0.000211916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1147482,"threshold_uncertainty_score":0.6068538,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2530757024059997,"score_gpt":0.4102627279802323,"score_spread":0.1571870255742326,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}