{"id":"W2032183920","doi":"10.1038/onc.2010.392","title":"A novel source of tetraploid cancer cell precursors: telomere insufficiency links aging to oncogenesis","year":2010,"lang":"en","type":"review","venue":"Oncogene","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Cancer Research; Institut National Du Cancer; Ligue Contre le Cancer","keywords":"Biology; Telomere; Endoreduplication; Carcinogenesis; Telomerase; Cancer; Aneuploidy; Mitosis; Cell cycle; Genetics; Cancer research; Ploidy; Cell; DNA; Chromosome; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004989138,0.0009419417,0.001833388,0.001662065,0.0002396898,0.001141579,0.0009089711,0.001345127,0.001738402],"category_scores_gemma":[0.0005393467,0.0002498144,0.0003014573,0.001513887,0.0005494197,0.001326461,0.0005685374,0.001768818,0.001717724],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005639462,"about_ca_system_score_gemma":0.0005896274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004222534,"about_ca_topic_score_gemma":0.0008619723,"domain_scores_codex":[0.9998586,0.00001978364,0.00002250872,0.0000332099,0.0000526364,0.00001319388],"domain_scores_gemma":[0.999731,0.0001188066,0.00004651371,0.00001181931,0.00006656626,0.00002523048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001342624,0.00009245568,0.0003331998,0.009984119,0.00007928785,0.0006198728,0.0000600598,0.0003541739,0.01208739,0.005360494,0.026976,0.9439186],"study_design_scores_gemma":[0.0000418647,0.0001337823,0.001410763,0.001613528,0.0001676216,0.004493746,0.0001009107,0.000212448,0.004939686,0.004519751,0.9823248,0.0000410566],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002049946,0.998669,0.0002280432,0.0002260833,0.0001501234,0.000002737424,0.00001552176,0.000007947216,0.0004955204],"genre_scores_gemma":[0.001198058,0.9976102,0.0002546704,0.00017596,0.0001876701,0.000006439552,0.00003445774,0.000001545683,0.0005309114],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001833388,"threshold_uncertainty_score":0.005815506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0486052618572999,"score_gpt":0.3516639584927208,"score_spread":0.3030586966354209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}