{"id":"W2032199025","doi":"10.2174/1568009023333926","title":"Mutant Epidermal Growth Factor Receptors as Targets for Cancer Therapy","year":2002,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"","keywords":"Receptor; Epidermal growth factor receptor; Epidermal growth factor; Cancer research; Extracellular; Biology; Tyrosine kinase; Epitope; Cancer; Receptor tyrosine kinase; Cancer cell; Mutant; Growth factor receptor; Mutation; Growth factor receptor inhibitor; Antibody; Cell biology; Immunology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006299525,0.0007172528,0.001288973,0.002025222,0.0002791617,0.0008301669,0.0008853594,0.001191832,0.004005027],"category_scores_gemma":[0.0004026117,0.0002298917,0.0003931427,0.001745811,0.0004627461,0.001185672,0.0004508458,0.001669686,0.003575687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008157654,"about_ca_system_score_gemma":0.0005599665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006383507,"about_ca_topic_score_gemma":0.001320694,"domain_scores_codex":[0.9997746,0.0000457367,0.00001873007,0.00002828221,0.0001131863,0.00001940346],"domain_scores_gemma":[0.9998739,0.0000521041,0.00001533394,0.000005781581,0.0000365327,0.0000163583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001297799,0.0001691361,0.0001559286,0.006829886,0.0000686452,0.0004931891,0.00008326564,0.0005925024,0.005554898,0.008057117,0.04197028,0.9358953],"study_design_scores_gemma":[0.00003933404,0.0001018632,0.0003767978,0.0008640452,0.00003616896,0.001297172,0.0000318558,0.00009203702,0.0008212007,0.002024931,0.9943048,0.000009677078],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002581779,0.9961537,0.0002346601,0.0003415685,0.0002553672,0.000009021206,0.00001261967,0.0000126308,0.002722234],"genre_scores_gemma":[0.001191223,0.9955896,0.0003325839,0.0003452633,0.0001570369,0.00001245456,0.00002723101,0.000002314358,0.002342205],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004005027,"threshold_uncertainty_score":0.01339811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673419595737975,"score_gpt":0.4593383807002334,"score_spread":0.2919964211264359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}