{"id":"W2032199025","doi":"10.2174/1568009023333926","title":"Mutant Epidermal Growth Factor Receptors as Targets for Cancer Therapy","year":2002,"lang":"en","type":"review","venue":"Current Cancer Drug Targets","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Regional Cancer Foundation","funders":"","keywords":"Receptor; Epidermal growth factor receptor; Epidermal growth factor; Cancer research; Extracellular; Biology; Tyrosine kinase; Epitope; Cancer; Receptor tyrosine kinase; Cancer cell; Mutant; Growth factor receptor; Mutation; Growth factor receptor inhibitor; Antibody; Cell biology; Immunology; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0006487587,0.001786817,0.004808611,0.0007336297,0.0003696609,0.0001220073,0.001111101,0.0006787755,0.01517432],"category_scores_gemma":[0.0004652197,0.001387536,0.002107522,0.001020791,0.00034278,0.0002257055,0.0002382863,0.002377512,0.0005379965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003578826,"about_ca_system_score_gemma":0.004642397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000868723,"about_ca_topic_score_gemma":0.0001196225,"domain_scores_codex":[0.9914201,0.0004557805,0.001853753,0.002179975,0.001738193,0.002352239],"domain_scores_gemma":[0.9950316,0.0005784906,0.000974234,0.001233217,0.0009497646,0.001232713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001157892,0.0003179314,0.0001395552,0.03265094,0.0007627598,0.00004061937,0.0004412232,7.320617e-7,0.00000496963,0.00003231419,0.1675847,0.7979085],"study_design_scores_gemma":[0.001950321,0.0002317518,0.00001492101,0.02664339,0.0007829056,0.00003705114,0.00001823144,0.00002928825,0.0003478258,0.00006257142,0.9685433,0.001338427],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00004072738,0.9725307,0.00003859626,0.001387797,0.01368873,0.008563158,0.002945218,0.0002805855,0.0005245226],"genre_scores_gemma":[0.00003446104,0.9745407,0.0001473595,0.0003508656,0.00643283,0.01256539,0.0007473466,0.0005821708,0.00459884],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8009586,"threshold_uncertainty_score":0.9999241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1673419595737975,"score_gpt":0.4593383807002334,"score_spread":0.2919964211264359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}