{"id":"W2032219297","doi":"10.1021/jo7021422","title":"A Regioselective Approach to Trisubstituted 2 (or 6)-Arylaminopyrimidine-5-carbaldehydes and Their Application in the Synthesis of Structurally and Electronically Unique G∧C Base Precursors","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Institute for Nanotechnology; University of Alberta","funders":"Solar Energy Technologies Office","keywords":"Regioselectivity; Chemistry; Nucleophilic aromatic substitution; Combinatorial chemistry; Bicyclic molecule; Catalysis; Nucleophile; Aniline; Alkoxide; Nucleophilic substitution; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004593676,0.0001470836,0.0002653208,0.00002289166,0.00006357121,0.000008667754,0.0003380584,0.0001029506,0.000006036433],"category_scores_gemma":[0.0004481103,0.00007405176,0.0000707174,0.0002391767,0.0001548656,0.000006042164,0.00005880972,0.0001850246,5.483519e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000249757,"about_ca_system_score_gemma":0.000114506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000116411,"about_ca_topic_score_gemma":0.00001196122,"domain_scores_codex":[0.9991437,0.00009356662,0.0003292231,0.0001627209,0.000126367,0.0001443761],"domain_scores_gemma":[0.9991685,0.0001848452,0.0002465086,0.0002403654,0.00009845039,0.00006131265],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236895,0.00007026771,0.0003022305,0.00003012873,0.00009166158,0.000001082733,0.0003656421,0.00001330191,0.9976203,0.000003676653,0.00007266211,0.00110537],"study_design_scores_gemma":[0.0002525678,0.00007576143,0.001667426,0.00002317045,0.00008215052,0.000582942,0.0004715738,0.00007385674,0.9964903,0.00008142779,0.00009974401,0.00009910319],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974385,0.0009069816,0.0009845698,0.0003697799,0.000002566369,0.0001178213,0.000005056662,0.000002010695,0.0001726339],"genre_scores_gemma":[0.998192,0.001308174,0.0003141433,0.00006605918,0.00007114071,0.000006872183,0.000003023524,0.00001119485,0.00002737618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001365195,"threshold_uncertainty_score":0.3019743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007905595620054372,"score_gpt":0.2065251826425516,"score_spread":0.1986195870224972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}