{"id":"W2032226815","doi":"10.4161/trns.20496","title":"Endocrine resistance in breast cancer: From cellular signaling pathways to epigenetic mechanisms","year":2012,"lang":"en","type":"review","venue":"Transcription","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Chromatin; Endocrine system; Biology; Signal transduction; Estrogen receptor; Breast cancer; Bioinformatics; Regulation of gene expression; Merge (version control); Cancer research; Gene; Cancer; Genetics; Hormone; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003194615,0.0006797046,0.00107339,0.001382816,0.0002170437,0.0006523755,0.0006350094,0.0007184586,0.00198573],"category_scores_gemma":[0.0003547304,0.000165972,0.000265793,0.001546311,0.0004118685,0.0008597611,0.0004731173,0.001060919,0.001451447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005319209,"about_ca_system_score_gemma":0.0005705471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007298649,"about_ca_topic_score_gemma":0.00142063,"domain_scores_codex":[0.9999011,0.00001652104,0.0000143106,0.00001830971,0.00003798045,0.00001171623],"domain_scores_gemma":[0.9998556,0.00005927739,0.00002184413,0.000004933533,0.00004199626,0.00001640071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005410623,0.0000397441,0.0002581023,0.01018162,0.00006096255,0.0003276743,0.00004737628,0.0002979324,0.004610144,0.002884484,0.01979389,0.961444],"study_design_scores_gemma":[0.00001339838,0.0001024586,0.001878066,0.002090982,0.000118731,0.003032774,0.00009576098,0.00009834586,0.001752331,0.002656222,0.9881359,0.00002493609],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001279378,0.9988145,0.000170916,0.0002239984,0.0001192332,0.000002099446,0.00001147113,0.000007511008,0.0005223443],"genre_scores_gemma":[0.0006518823,0.9985906,0.0001404487,0.0001106817,0.0001113983,0.000002618118,0.00001432546,9.465263e-7,0.0003769459],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00198573,"threshold_uncertainty_score":0.006642938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02338594743240428,"score_gpt":0.2610584177835479,"score_spread":0.2376724703511436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}