{"id":"W2032247829","doi":"10.1124/jpet.105.093179","title":"Inhibition of Inducible Nitric-Oxide Synthase Expression by (5 R)-5-Hydroxytriptolide in Interferon-γ- and Bacterial Lipopolysaccharide-Stimulated Macrophages","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Lipopolysaccharide; Nitric oxide synthase; Nitric oxide; ATP synthase; Chemistry; Microbiology; Interferon γ; Interferon; Molecular biology; Interferon gamma; Biochemistry; Immunology; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004552402,0.0004266583,0.0004397287,0.0002132862,0.0001914963,0.0002909423,0.0003176829,0.000392809,0.001277297],"category_scores_gemma":[0.0001929909,0.0002467028,0.0004610384,0.0001663326,0.000354948,0.0002306989,0.0001592497,0.000885907,0.0005161561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002546255,"about_ca_system_score_gemma":0.0003789302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005427075,"about_ca_topic_score_gemma":0.0007303029,"domain_scores_codex":[0.9996966,0.00008964041,0.00003769849,0.00002661842,0.00005092732,0.00009857184],"domain_scores_gemma":[0.9997414,0.00006812059,0.0000564933,0.00004512663,0.00002819351,0.00006063153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001600846,0.00008892052,0.00009666049,0.00003905891,0.000005496705,0.00007987821,0.00002309736,0.00009517914,0.9968643,0.0001084949,0.00004658655,0.0009514924],"study_design_scores_gemma":[0.0001238063,0.001084787,0.001396942,0.000005378639,0.00001406594,0.00008365928,0.0000340028,0.0007093469,0.9960203,0.00005140619,0.0004715993,0.000004781206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995472,0.0009444291,0.001583551,0.000177754,0.00009844908,0.0000459354,0.0002999226,0.00006754546,0.001310294],"genre_scores_gemma":[0.9948856,0.0006370315,0.001282147,0.00006724224,0.000036594,0.00008908133,0.0003461392,0.00001383721,0.002642279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277297,"threshold_uncertainty_score":0.004272997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318725430291699,"score_gpt":0.3054942447642651,"score_spread":0.2923069904613481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}