{"id":"W2032247829","doi":"10.1124/jpet.105.093179","title":"Inhibition of Inducible Nitric-Oxide Synthase Expression by (5 R)-5-Hydroxytriptolide in Interferon-γ- and Bacterial Lipopolysaccharide-Stimulated Macrophages","year":2005,"lang":"en","type":"article","venue":"Journal of Pharmacology and Experimental Therapeutics","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute for Biological Sciences","funders":"","keywords":"Lipopolysaccharide; Nitric oxide synthase; Nitric oxide; ATP synthase; Chemistry; Microbiology; Interferon γ; Interferon; Molecular biology; Interferon gamma; Biochemistry; Immunology; Biology; Enzyme; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001981483,0.0001515369,0.0002397057,0.0001050957,0.00004181589,0.00001341088,0.00007968501,0.0001645826,0.00007113566],"category_scores_gemma":[0.000002987423,0.0001378375,0.00005078183,0.00004628974,0.0001001726,0.00002278314,0.00007485061,0.0001666147,3.389528e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003540325,"about_ca_system_score_gemma":0.00004403419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007869572,"about_ca_topic_score_gemma":0.000001528764,"domain_scores_codex":[0.9990873,0.00008503272,0.0004082636,0.0001636676,0.00008967385,0.0001660092],"domain_scores_gemma":[0.9995437,0.00001872175,0.0002584559,0.00006422148,0.00004618678,0.00006877296],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002173674,0.0003246699,0.00007501226,0.000009963725,0.00009178142,0.000006300744,0.0002337335,0.00003145172,0.9948599,0.00000634667,0.0001961522,0.001991021],"study_design_scores_gemma":[0.003368311,0.0008424345,0.00002607411,0.00003040886,0.00005038988,0.00007512593,0.0002363298,0.000136942,0.9919651,0.00003030193,0.00311043,0.0001281798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904951,0.008840149,0.0001709822,0.0001308354,0.0002175461,0.0001132574,0.00001635885,0.000002511111,0.00001321892],"genre_scores_gemma":[0.9964001,0.002345043,0.0003890848,0.0006159665,0.0001937351,0.000004874561,0.000008651302,0.00001677637,0.000025825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006495106,"threshold_uncertainty_score":0.5620852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01318725430291699,"score_gpt":0.3054942447642651,"score_spread":0.2923069904613481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}