{"id":"W2032284140","doi":"10.1002/1526-968x(200011/12)28:3/4<147::aid-gene90>3.0.co;2-g","title":"Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excision","year":2000,"lang":"en","type":"article","venue":"genesis","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":832,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Sunnybrook Health Science Centre","funders":"Medical Research Council; Cancer Care Ontario","keywords":"Cre recombinase; Green fluorescent protein; Biology; Transgene; Molecular biology; Recombinase; lac operon; Embryonic stem cell; Reporter gene; Cre-Lox recombination; Genetically modified mouse; Gene; Cell culture; Gene knockin; Cell biology; Genetics; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001122281,0.0002211503,0.0001795683,0.00004549302,0.00006581466,0.00002851193,0.0001803859,0.0001745412,0.0003672026],"category_scores_gemma":[0.00001859572,0.0002049609,0.000105534,0.00009134355,0.00002247274,0.000005255255,0.00007212401,0.00005636791,0.00005079746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000125454,"about_ca_system_score_gemma":0.00003288797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001353478,"about_ca_topic_score_gemma":0.00006934266,"domain_scores_codex":[0.9987194,0.00002495988,0.0002672251,0.0004670452,0.0001964681,0.0003249338],"domain_scores_gemma":[0.999186,0.000005461079,0.00005928998,0.0005678629,0.00005828633,0.0001230411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002693136,0.00006054839,0.00009047507,0.00003360083,0.00003233756,0.000009014093,0.00007503713,0.000807196,0.9820532,3.45464e-7,0.0006719141,0.01589706],"study_design_scores_gemma":[0.0007408051,0.0001464085,0.000858584,0.00002300797,0.00001711683,0.00000959446,0.00002922555,0.0001473188,0.9705526,0.00000428864,0.02721209,0.0002589789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933057,0.001320895,0.0043556,0.00008618752,0.00007200924,0.0004054448,0.00001703202,0.00005483212,0.0003822875],"genre_scores_gemma":[0.991239,0.0005630864,0.001243361,0.00007847678,0.0002918726,0.0001236964,0.0001940293,0.00004708268,0.006219376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02654018,"threshold_uncertainty_score":0.8358062,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01192882819464259,"score_gpt":0.2719604343695559,"score_spread":0.2600316061749133,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}