{"id":"W2032294094","doi":"10.1038/cddis.2011.119","title":"Musashi expression in β-cells coordinates insulin expression, apoptosis and proliferation in response to endoplasmic reticulum stress in diabetes","year":2011,"lang":"en","type":"article","venue":"Cell Death and Disease","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Vancouver General Hospital","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC; Stem Cell Network","keywords":"Cell biology; HES1; NUMB; Biology; Endoplasmic reticulum; Gene knockdown; Unfolded protein response; Insulin; Notch signaling pathway; Cellular differentiation; Embryonic stem cell; Cell growth; Stem cell; Endocrinology; Signal transduction; Internal medicine; Apoptosis; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077046,0.0002461071,0.0002269291,0.0002507135,0.0001466886,0.0002951557,0.000125196,0.0001614622,0.0007665295],"category_scores_gemma":[0.00006762622,0.0001535295,0.0001767205,0.0001820202,0.0001624645,0.0002056,0.0002562477,0.0003964193,0.0002143653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002018313,"about_ca_system_score_gemma":0.00009258874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002628701,"about_ca_topic_score_gemma":0.0003501002,"domain_scores_codex":[0.9999176,0.000009568063,0.00001196427,0.00002529118,0.0000183522,0.00001720119],"domain_scores_gemma":[0.9999322,0.000005199473,0.00001889396,0.000007340415,0.0000117474,0.00002453411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000099069,0.000005032929,0.0004130583,0.00002678752,0.000004985206,0.00003810907,0.00001473119,0.00001058244,0.9983879,0.00003853013,0.00001358898,0.0009475877],"study_design_scores_gemma":[0.0000185187,0.0002159543,0.03859464,0.00001512799,0.00005280269,0.0007551298,0.0001214437,0.0004027691,0.9540276,0.0001456817,0.005640455,0.000009859965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98785,0.007375736,0.002747273,0.0000875128,0.00005416585,0.00001482204,0.0002450022,0.00009426811,0.001531081],"genre_scores_gemma":[0.9916629,0.003353621,0.001419494,0.00006226343,0.00002419608,0.00002192261,0.0003401204,0.0000207907,0.003094641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007665295,"threshold_uncertainty_score":0.002564251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169887850348319,"score_gpt":0.2192927687899208,"score_spread":0.2075938902864377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}