{"id":"W2032304802","doi":"10.1126/scitranslmed.3004062","title":"Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression","year":2012,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research","funders":"National Cancer Institute; National Heart, Lung, and Blood Institute","keywords":"Matrix metalloproteinase; Effector; Lung cancer; Metalloproteinase; Matrix metalloproteinase 9; Adenocarcinoma; Cancer research; Cancer; Epithelial–mesenchymal transition; Lung; Medicine; Matrix (chemical analysis); Biology; Pathology; Immunology; Internal medicine; Chemistry; Metastasis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007486031,0.00007523887,0.0001178817,0.00008588062,0.00005241121,0.000001467852,0.0001098558,0.00004396184,0.00009428751],"category_scores_gemma":[0.00008675161,0.00005387697,0.00003489005,0.000264312,0.0003510781,0.00002303114,0.0000154702,0.00004503876,6.172996e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000780393,"about_ca_system_score_gemma":0.0001334275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003056079,"about_ca_topic_score_gemma":0.000001708723,"domain_scores_codex":[0.9990329,0.00002973108,0.0001931841,0.0001485724,0.0004317265,0.0001639055],"domain_scores_gemma":[0.9995259,0.000008104355,0.0001128711,0.0001218151,0.0001468458,0.00008445587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006928869,0.00004619512,0.002153915,0.00006681308,0.00001020054,8.982986e-8,0.0001341016,0.000009689771,0.9945417,0.0007093832,0.0000391101,0.00221948],"study_design_scores_gemma":[0.0005237773,0.0002181273,0.003820057,0.0001424829,0.00002895976,0.000003303252,0.0000199649,0.0001299041,0.9946881,0.0001009212,0.0002656579,0.00005875028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9898891,0.005784703,0.002983668,0.000395438,0.0003445883,0.000375734,0.0000138593,0.000004608243,0.0002082826],"genre_scores_gemma":[0.9977316,0.00004108566,0.001782104,0.00002308479,0.0003316515,0.00003747021,0.00002165954,0.000005020176,0.00002628295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007842523,"threshold_uncertainty_score":0.2197039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01308891701708892,"score_gpt":0.344247097468454,"score_spread":0.3311581804513651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}