{"id":"W2032305014","doi":"10.1021/jo060430t","title":"Solventless Protocol for Efficient Bis-<i>N</i>-Boc Protection of Adenosine, Cytidine, and Guanosine Derivatives","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cytidine; Guanosine; Chemistry; Deoxyguanosine; Moiety; Silylation; Adenosine; Guanine; Stereochemistry; Deoxyadenosine; Nucleotide; Nucleic acid; Organic chemistry; Biochemistry; Adduct; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002742891,0.0006003195,0.0003576044,0.0002434451,0.0003508559,0.000170037,0.000706206,0.0003370084,0.002417667],"category_scores_gemma":[0.0001747652,0.0003528333,0.0002503672,0.0002570089,0.0002196939,0.0003191829,0.0003139036,0.001036222,0.001271154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002063046,"about_ca_system_score_gemma":0.0004938297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003506963,"about_ca_topic_score_gemma":0.0009627145,"domain_scores_codex":[0.9997901,0.00003431158,0.0000225435,0.00005479107,0.00005716539,0.00004107236],"domain_scores_gemma":[0.9998965,0.00002201447,0.00002381835,0.00002319831,0.00001719286,0.00001723334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005998751,0.00003831135,0.00002677516,0.0001190682,0.000005855776,0.00009286113,0.00004373175,0.0001105549,0.994454,0.0005076487,0.0002995753,0.004241745],"study_design_scores_gemma":[0.00002928911,0.0002326138,0.0003457234,0.000005405003,0.00001315251,0.000442699,0.0000115476,0.000473781,0.9889094,0.0001563222,0.00936368,0.00001634277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4950376,0.004131866,0.4749416,0.0003678391,0.0004618492,0.001492205,0.001624765,0.002151795,0.01979051],"genre_scores_gemma":[0.8156818,0.004609375,0.1626826,0.0002672062,0.00008772971,0.001273999,0.002430569,0.0003297275,0.0126371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002417667,"threshold_uncertainty_score":0.008087873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148551569786903,"score_gpt":0.2664915318098648,"score_spread":0.2516363748311746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}