{"id":"W2032305014","doi":"10.1021/jo060430t","title":"Solventless Protocol for Efficient Bis-<i>N</i>-Boc Protection of Adenosine, Cytidine, and Guanosine Derivatives","year":2006,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Cytidine; Guanosine; Chemistry; Deoxyguanosine; Moiety; Silylation; Adenosine; Guanine; Stereochemistry; Deoxyadenosine; Nucleotide; Nucleic acid; Organic chemistry; Biochemistry; Adduct; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002399374,0.0001367047,0.0002767566,0.00003578345,0.00006939943,0.000008677724,0.00007849098,0.00005646225,0.0001028881],"category_scores_gemma":[0.00006946001,0.00008137584,0.00007115008,0.0001562041,0.00007943201,0.00002832388,0.000026927,0.0001304596,6.24215e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008355501,"about_ca_system_score_gemma":0.0001978893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002868139,"about_ca_topic_score_gemma":8.987506e-7,"domain_scores_codex":[0.9990851,0.00001584994,0.0004453671,0.00008817613,0.0002333076,0.0001321474],"domain_scores_gemma":[0.9990955,0.00005420564,0.0004377698,0.0001223354,0.0002391556,0.00005102634],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008280743,0.0004940326,0.001555394,0.0005745845,0.0001170773,0.000006673901,0.0001870517,0.00001507672,0.994473,0.000005536543,0.001443944,0.0002994887],"study_design_scores_gemma":[0.004508628,0.0001732223,0.002486699,0.0003945545,0.0001704358,0.0004539554,0.0002316211,0.00006248181,0.9888918,0.00004612289,0.002499746,0.0000807593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661406,0.000192427,0.004024201,0.003512793,0.00003302443,0.02563826,0.000005872296,0.00001711171,0.000435724],"genre_scores_gemma":[0.9935811,0.000009646215,0.001509276,0.00001626141,0.0002594635,0.002461223,0.00000443783,0.00002745505,0.00213112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02744053,"threshold_uncertainty_score":0.3318411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148551569786903,"score_gpt":0.2664915318098648,"score_spread":0.2516363748311746,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}