{"id":"W2032306637","doi":"10.1074/jbc.m011246200","title":"Mutation of a Single Conserved Tryptophan in Multidrug Resistance Protein 1 (MRP1/ABCC1) Results in Loss of Drug Resistance and Selective Loss of Organic Anion Transport","year":2001,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":165,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"ABCC1; ATP-binding cassette transporter; Transfection; Biochemistry; Biology; Molecular biology; Chemistry; Transporter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001403609,0.0004672479,0.0003450377,0.0001927364,0.000181645,0.0002733318,0.0003471856,0.0005179091,0.001274354],"category_scores_gemma":[0.0001946548,0.0002015384,0.0004617731,0.0002023302,0.0002947834,0.0001668151,0.0003076703,0.0005349477,0.0007133791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000279694,"about_ca_system_score_gemma":0.0002119266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005099667,"about_ca_topic_score_gemma":0.000378997,"domain_scores_codex":[0.9997856,0.00004878321,0.00003844974,0.00004366544,0.00005352619,0.00003000555],"domain_scores_gemma":[0.9997413,0.00004896749,0.000112928,0.0000351289,0.00001831073,0.00004330029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008508376,0.000031829,0.0001500466,0.00002544282,0.00001186912,0.0002594133,0.00001221011,0.00005022629,0.9984464,0.00007644599,0.00002971762,0.0008212963],"study_design_scores_gemma":[0.00003676935,0.0003344605,0.002914642,0.000006884532,0.00003273544,0.001576771,0.00003147689,0.001026215,0.9907108,0.00004652223,0.003271004,0.00001178296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962727,0.0004515212,0.002312234,0.00008273161,0.00003364997,0.00003997863,0.0003290219,0.00008802477,0.0003903095],"genre_scores_gemma":[0.9952314,0.0003995785,0.001872695,0.00003432284,0.00001193026,0.0000364761,0.0005769773,0.00004402007,0.001792437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274354,"threshold_uncertainty_score":0.004263103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01442097149542071,"score_gpt":0.238612775065196,"score_spread":0.2241918035697752,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}