{"id":"W2032311175","doi":"10.1016/j.ymben.2009.06.001","title":"Quantification of statin effects on hepatic cholesterol synthesis by transient 13C-flux analysis","year":2009,"lang":"en","type":"article","venue":"Metabolic Engineering","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bundesministerium für Bildung und Forschung; Atlantic Canada Opportunities Agency; Robert Bosch Stiftung","keywords":"Flux (metallurgy); Statin; Metabolic flux analysis; Transient (computer programming); Cholesterol; Atorvastatin; Chemistry; Internal medicine; Biochemistry; Medicine; Computer science; Metabolism; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007722739,0.0007073589,0.001113346,0.0005500834,0.0007219793,0.001011005,0.0004469472,0.000545731,0.002222744],"category_scores_gemma":[0.0006140159,0.0003542901,0.0006780121,0.001069942,0.0008929567,0.0005581224,0.000438122,0.0009321553,0.0003718768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001387605,"about_ca_system_score_gemma":0.001154585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006846718,"about_ca_topic_score_gemma":0.009472098,"domain_scores_codex":[0.9995389,0.00009108092,0.00003866043,0.0001114887,0.0001169928,0.0001029437],"domain_scores_gemma":[0.999494,0.0001761804,0.00006777997,0.00009166379,0.0001029155,0.00006747716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002530297,0.00007732202,0.0006397247,0.00008840075,0.00003703182,0.00002945785,0.00004574145,0.0005059172,0.992474,0.0003658076,0.0001051824,0.003100943],"study_design_scores_gemma":[0.00004227605,0.0001518363,0.001759883,0.000003129042,0.00003686138,0.00001550324,0.00001790898,0.002612597,0.9946824,0.0000542235,0.0006129111,0.00001041601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9610746,0.001643173,0.02980057,0.0002711214,0.0001365121,0.0001787142,0.003881474,0.0003321801,0.002681561],"genre_scores_gemma":[0.9609345,0.001289379,0.02825435,0.0002110634,0.00004455295,0.0004799595,0.003425564,0.0002687694,0.00509193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006846718,"threshold_uncertainty_score":0.01361376,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009348703495255458,"score_gpt":0.2395474225735756,"score_spread":0.2301987190783201,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}