{"id":"W2032317721","doi":"10.1128/jvi.03233-12","title":"Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins","year":2013,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver; Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"CTL*; Biology; Mutation; Genetics; Cytotoxic T cell; CD8; Viral replication; Virology; Virus; Gene; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004743417,0.0004332379,0.0003335267,0.0002650751,0.0002080181,0.0004338128,0.0002669875,0.0003819706,0.0005505426],"category_scores_gemma":[0.0009535389,0.0001579656,0.0002554267,0.0003232407,0.0002542199,0.0003803393,0.0002429783,0.0005785539,0.00008803027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004992285,"about_ca_system_score_gemma":0.0001988327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182525,"about_ca_topic_score_gemma":0.001964684,"domain_scores_codex":[0.9996033,0.00007489223,0.00003168356,0.00008043151,0.0001673409,0.00004236402],"domain_scores_gemma":[0.9996098,0.0001920165,0.0001072216,0.00002873072,0.00003717478,0.00002507451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002322089,0.0002379691,0.02388362,0.0001835893,0.000126082,0.0001781715,0.0000590181,0.02847662,0.9307638,0.0005177099,0.000128222,0.01521309],"study_design_scores_gemma":[0.00003588458,0.001824414,0.08673102,0.00003034856,0.0001603613,0.0009346948,0.0001080263,0.1762965,0.7317858,0.000686448,0.001359125,0.00004741239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969869,0.0003959442,0.002137415,0.00001552255,0.000003005619,0.00001270127,0.000098393,0.00002487995,0.0003253201],"genre_scores_gemma":[0.9977916,0.0001486933,0.00177997,0.00001760528,0.000001137866,0.00001136763,0.0001406096,0.000007497008,0.0001012981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182525,"threshold_uncertainty_score":0.003622234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01437227961545597,"score_gpt":0.2605695146485819,"score_spread":0.2461972350331259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}